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Histamine-neuron activity therefore contributes to sustained wakefulness in that setting, without being established as the direct drug target. Recovery sleep still showed increased NREM delta power, including after histamine-neuron ablation: a homeostatic response persisted. [Histamine-neuron study, 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6519916/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"45dfd24f-5994-5586-b2c1-a4139b201856","slug":"mouse-histamine-neurons","display_name":"Mouse histamine-producing neurons","entity_type_key":"cell_type"},"role":"tested factor","stoichiometry":null,"state_label":"Histamine-neuron ablation/inhibition plus modafinil","sequence_order":0,"notes":""},{"entity":{"id":"2783faf9-3c82-5360-8540-e30f0f7310a1","slug":"mouse-wake-duration","display_name":"Mouse wake duration","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""},{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"drug challenge","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"847daefd-ce13-541a-b426-919975168a3d","slug":"histamine","display_name":"Histamine","entity_type_key":"small_molecule"},"role":"transmitter identity","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Full XML obtained; relevant results/methods inspected. 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Histamine-neuron activity therefore contributes to sustained wakefulness in that setting, without being established as the direct drug target. Recovery sleep still showed increased NREM delta power, including after histamine-neuron ablation: a homeostatic response persisted. [Histamine-neuron study, 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6519916/)","model_system":"Mouse genetic and chemogenetic experiments; cell dependency not direct drug binding.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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