{"id":"98bbb380-8ff1-5f5c-8ba0-fa5a3764bd7d","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:sleep-pressure","predicate":"increases_in_recorded_experiment","statement":"Recovery sleep showed increased NREM delta power after modafinil, including after histamine-neuron ablation; prolonged waking did not remove this homeostatic response.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"d7f792fb-65a7-5a4a-a987-8b2dfe9ccb75","mechanism_event_label":"Recovery sleep showed increased NREM delta power after modafinil, including after histamine-neuron ablation; prolonged waking did not remove this homeostatic response.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"c7d9f410-5df1-566e-bc99-4399d095ad88","slug":"mouse-nrem-delta-power","display_name":"Mouse recovery-sleep NREM delta power","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d7f792fb-65a7-5a4a-a987-8b2dfe9ccb75","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:sleep-pressure-event","event_type":"experimental_observation","label":"Recovery sleep showed increased NREM delta power after modafinil, including after histamine-neuron ablation; prolonged waking did not remove this homeostatic response.","description":"Genetic removal or acute chemogenetic inhibition of histamine neurons shortened modafinil-induced waking in mice rather than abolishing it. 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[Histamine-neuron study, 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6519916/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Post-modafinil recovery sleep","sequence_order":0,"notes":""},{"entity":{"id":"c7d9f410-5df1-566e-bc99-4399d095ad88","slug":"mouse-nrem-delta-power","display_name":"Mouse recovery-sleep NREM delta power","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""},{"entity":{"id":"45dfd24f-5994-5586-b2c1-a4139b201856","slug":"mouse-histamine-neurons","display_name":"Mouse histamine-producing neurons","entity_type_key":"cell_type"},"role":"manipulated cell population","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Full XML obtained; relevant results/methods inspected. 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