Component

Mouse growth arrest-specific protein 6 / Gas6

Mouse growth arrest-specific protein 6 / Gas6. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Increasing marrow GAS6 in transgenic male mice increased osteoclast number and size and decreased bone mass.

    Mouse growth arrest-specific protein 6 / Gas6 → Bone mass source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"}
    experimental_model
    Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression
    exposure
    Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation
    limitations
    2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    Male mice and mouse osteoblast/osteoclast cultures
    plain_language
    More of this signal changed the balance toward bone resorption in the mouse model.
    primary_references
    [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
    tissue_or_cell_type
    Bone remodeling

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 682–693

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression · source_derived_draft · unverified_draft

    ### k2-gas6-bone-mass Increasing marrow GAS6 in transgenic male mice increased osteoclast number and size and decreased bone mass. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: More of this signal changed the balance toward bone resorption in the mouse model. organism: Male mice and mouse osteoblast/osteoclast cultures tissue_or_cell_type: Bone remodeling experimental_model: Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression limitations: 2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested. exposure: Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation evidence_span: {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"} [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Recombinant carboxylated GAS6 increased precursor fusion, osteoclast size and nuclei per osteoclast in culture.

    Gamma-carboxylated mouse GAS6 → Fusion of osteoclast precursors source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"}
    experimental_model
    Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression
    exposure
    Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation
    limitations
    2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    Male mice and mouse osteoblast/osteoclast cultures
    plain_language
    One modified protein helps bone-resorbing cells mature.
    primary_references
    [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
    tissue_or_cell_type
    Bone remodeling

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 643–654

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression · source_derived_draft · unverified_draft

    ### k2-gas6-fusion Recombinant carboxylated GAS6 increased precursor fusion, osteoclast size and nuclei per osteoclast in culture. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: One modified protein helps bone-resorbing cells mature. organism: Male mice and mouse osteoblast/osteoclast cultures tissue_or_cell_type: Bone remodeling experimental_model: Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression limitations: 2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested. exposure: Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation evidence_span: {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"} [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
    Complete structured claim and evidence

  2. Pharmacological inhibition of mouse-axl blocked osteoclast generation in the co-culture system.

    Mouse Axl receptor tyrosine kinase → Osteoclast maturation and multinucleation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"}
    experimental_model
    Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression
    exposure
    Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation
    limitations
    2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    Male mice and mouse osteoblast/osteoclast cultures
    plain_language
    The receptor is a separate intervention point in this pathway.
    primary_references
    [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
    tissue_or_cell_type
    Bone remodeling

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 656–667

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression · source_derived_draft · unverified_draft

    ### k2-mouse-axl-osteoclast Pharmacological inhibition of mouse-axl blocked osteoclast generation in the co-culture system. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor is a separate intervention point in this pathway. organism: Male mice and mouse osteoblast/osteoclast cultures tissue_or_cell_type: Bone remodeling experimental_model: Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression limitations: 2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested. exposure: Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation evidence_span: {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"} [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
    Complete structured claim and evidence

  3. Pharmacological inhibition of mouse-mertk blocked osteoclast generation in the co-culture system.

    Mouse Mertk receptor tyrosine kinase → Osteoclast maturation and multinucleation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"}
    experimental_model
    Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression
    exposure
    Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation
    limitations
    2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    Male mice and mouse osteoblast/osteoclast cultures
    plain_language
    The receptor is a separate intervention point in this pathway.
    primary_references
    [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
    tissue_or_cell_type
    Bone remodeling

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 669–680

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression · source_derived_draft · unverified_draft

    ### k2-mouse-mertk-osteoclast Pharmacological inhibition of mouse-mertk blocked osteoclast generation in the co-culture system. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor is a separate intervention point in this pathway. organism: Male mice and mouse osteoblast/osteoclast cultures tissue_or_cell_type: Bone remodeling experimental_model: Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression limitations: 2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested. exposure: Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation evidence_span: {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"} [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards