Component
Fusion of osteoclast precursors
Fusion of osteoclast precursors. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Recombinant carboxylated GAS6 increased precursor fusion, osteoclast size and nuclei per osteoclast in culture.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"}
- experimental_model
- Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression
- exposure
- Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation
- limitations
- 2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Male mice and mouse osteoblast/osteoclast cultures
- plain_language
- One modified protein helps bone-resorbing cells mature.
- primary_references
- [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
- tissue_or_cell_type
- Bone remodeling
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 643–654
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression · source_derived_draft · unverified_draft
### k2-gas6-fusion Recombinant carboxylated GAS6 increased precursor fusion, osteoclast size and nuclei per osteoclast in culture. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: One modified protein helps bone-resorbing cells mature. organism: Male mice and mouse osteoblast/osteoclast cultures tissue_or_cell_type: Bone remodeling experimental_model: Osteoblast-specific deletion, co-culture, receptor inhibitors and transgenic overexpression limitations: 2026 mouse study; increased bone mass is not proven improved human bone quality, and no oral MK-7 regimen was tested. exposure: Osteoblast Ggcx deletion; carboxylated GAS6 and AXL/MERTK perturbation evidence_span: {"source_cache": "artifacts/k2-research/42045170.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf", "start_char": 0, "end_char": 1703, "text_sha256": "590b559787319a57a3e2fae4164fc2f2a40761ce653bd426d34a2d76aff5d4cf"} [k2-p42045170] Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice. (2026). https://pubmed.ncbi.nlm.nih.gov/42045170/ DOI: 10.1038/s41413-026-00528-2
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.