Component
Mouse chemokine CXCL12
Context-specific entity; species, compartment and exposure are stated on each claim.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Adding mouse CXCL12 back to plasma from fisetin-treated old mice reduced dilation in recipient isolated mouse arteries.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Recombinant CXCL12 matched old-control plasma concentration of 3210 pg/mL.
- limitations
- Partial mediation; other plasma components remain involved.
- nutrient_topic
- Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Fisetin
- plain_language
- Replacing one secreted factor weakened the vascular improvement.
- primary_references
- Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42021544/ · DOI 10.1111/acel.70500
Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19) · lines 256–262
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Recombinant CXCL12 matched old-control plasma concentration of 3210 pg/mL. · source_derived_draft · unverified_draft
## fisetin-cxcl12-addback Replacing one secreted factor weakened the vascular improvement. Adding mouse CXCL12 back to plasma from fisetin-treated old mice reduced dilation in recipient isolated mouse arteries. Model: Recombinant CXCL12 matched old-control plasma concentration of 3210 pg/mL. Limitations: Partial mediation; other plasma components remain involved. Evidence access: Primary full text Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42021544/ · DOI 10.1111/acel.70500
Complete structured claim and evidence
What acts on it
Intermittent fisetin at 100 mg/kg/day reduced age-associated endothelial Cxcl12 expression and circulating CXCL12 in mice.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Young/old male and female mouse aortic single-cell and plasma analyses.
- limitations
- Changes in expression and circulating protein are not direct CXCL12 binding.
- nutrient_topic
- Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Fisetin
- plain_language
- A secreted signal connects cellular state to other vessels.
- primary_references
- Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42021544/ · DOI 10.1111/acel.70500
Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19) · lines 248–254
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Young/old male and female mouse aortic single-cell and plasma analyses. · source_derived_draft · unverified_draft
## fisetin-cxcl12-expression A secreted signal connects cellular state to other vessels. Intermittent fisetin at 100 mg/kg/day reduced age-associated endothelial Cxcl12 expression and circulating CXCL12 in mice. Model: Young/old male and female mouse aortic single-cell and plasma analyses. Limitations: Changes in expression and circulating protein are not direct CXCL12 binding. Evidence access: Primary abstract Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42021544/ · DOI 10.1111/acel.70500
Complete structured claim and evidence
Where it participates (unsigned role)
Old-mouse plasma reduced NO-related bioactivity and increased mitochondrial oxidative stress in cultured human aortic endothelial cells; fisetin treatment of donor mice attenuated these effects.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse plasma applied to human endothelial culture.
- limitations
- Cross-species ex vivo experiment, not human oral fisetin exposure.
- nutrient_topic
- Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Fisetin
- plain_language
- A plasma-transfer experiment tested effects on recipient cells.
- primary_references
- Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42021544/ · DOI 10.1111/acel.70500
Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19) · lines 264–270
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse plasma applied to human endothelial culture. · source_derived_draft · unverified_draft
## fisetin-cross-species-plasma A plasma-transfer experiment tested effects on recipient cells. Old-mouse plasma reduced NO-related bioactivity and increased mitochondrial oxidative stress in cultured human aortic endothelial cells; fisetin treatment of donor mice attenuated these effects. Model: Mouse plasma applied to human endothelial culture. Limitations: Cross-species ex vivo experiment, not human oral fisetin exposure. Evidence access: Primary abstract Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42021544/ · DOI 10.1111/acel.70500
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.