{"id":"994c7b2c-4b07-576a-9814-25eb2a2f6a2b","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-cxcl12-expression","predicate":"reduces","statement":"Intermittent fisetin at 100 mg/kg/day reduced age-associated endothelial Cxcl12 expression and circulating CXCL12 in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"ff5cc575-1176-5880-8762-8cdf5253d4a1","mechanism_event_label":"A secreted signal connects cellular state to other vessels.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"563d0083-0065-5949-a288-9c8283864e0c","slug":"mouse-cxcl12","display_name":"Mouse chemokine CXCL12","entity_type_key":"cytokine"},"evidence_count":1,"mechanism_event":{"id":"ff5cc575-1176-5880-8762-8cdf5253d4a1","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-cxcl12-expression-event","event_type":"observed_relationship","label":"A secreted signal connects cellular state to other vessels.","description":"Intermittent fisetin at 100 mg/kg/day reduced age-associated endothelial Cxcl12 expression and circulating CXCL12 in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"563d0083-0065-5949-a288-9c8283864e0c","slug":"mouse-cxcl12","display_name":"Mouse chemokine CXCL12","entity_type_key":"cytokine"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Young/old male and female mouse aortic single-cell and plasma analyses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Changes in expression and circulating protein are not direct CXCL12 binding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A secreted signal connects cellular state to other vessels.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42021544/ · DOI 10.1111/acel.70500","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"005f41e7-8cf5-52f1-a116-bfed7746b5e3","evidence_kind":"source_excerpt","locator":"Lines 248-254","start_line":248,"end_line":254,"excerpt":"## fisetin-cxcl12-expression\nA secreted signal connects cellular state to other vessels.\nIntermittent fisetin at 100 mg/kg/day reduced age-associated endothelial Cxcl12 expression and circulating CXCL12 in mice.\nModel: Young/old male and female mouse aortic single-cell and plasma analyses.\nLimitations: Changes in expression and circulating protein are not direct CXCL12 binding.\nEvidence access: Primary abstract\nSenolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42021544/ · DOI 10.1111/acel.70500","model_system":"Young/old male and female mouse aortic single-cell and plasma analyses.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}