Component

Experimental mouse Chdh-null genotype

Experimental mouse Chdh-null genotype. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Sperm ATP content was significantly reduced in Chdh-null males.

    Experimental mouse Chdh-null genotype → Mouse sperm ATP content source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/choline-research/20371614.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48", "start_char": 0, "end_char": 1334, "text_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48"}
    experimental_model
    Chdh-null mouse genetics and sperm biochemical assays
    exposure
    Chdh deletion versus wild type
    limitations
    Loss of an enzyme is not the same exposure as low dietary choline; mouse fertility results are not a human diagnostic rule. The 2018 correction replaces the original knockout exon diagram: exons 1–6 and much of exon 7 were deleted, not only exons 1–3 (PMID 29698116; doi:10.1096/fj.09-153718ERR).
    nutrient_topic
    Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
    organism
    Mouse
    plain_language
    The enzyme defect was associated with impaired sperm energetics.
    primary_references
    [choline-p20371614] Deletion of murine choline dehydrogenase results in diminished sperm motility. (2010). https://pubmed.ncbi.nlm.nih.gov/20371614/ DOI: 10.1096/fj.09-153718
    tissue_or_cell_type
    Testis and sperm mitochondria
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 581–592

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Chdh-null mouse genetics and sperm biochemical assays · source_derived_draft · unverified_draft

    ### choline-chdh-atp Sperm ATP content was significantly reduced in Chdh-null males. Condition category: machinery_impairment nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: The enzyme defect was associated with impaired sperm energetics. organism: Mouse tissue_or_cell_type: Testis and sperm mitochondria experimental_model: Chdh-null mouse genetics and sperm biochemical assays limitations: Loss of an enzyme is not the same exposure as low dietary choline; mouse fertility results are not a human diagnostic rule. The 2018 correction replaces the original knockout exon diagram: exons 1–6 and much of exon 7 were deleted, not only exons 1–3 (PMID 29698116; doi:10.1096/fj.09-153718ERR). exposure: Chdh deletion versus wild type evidence_span: {"source_cache": "artifacts/choline-research/20371614.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48", "start_char": 0, "end_char": 1334, "text_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48"} [choline-p20371614] Deletion of murine choline dehydrogenase results in diminished sperm motility. (2010). https://pubmed.ncbi.nlm.nih.gov/20371614/ DOI: 10.1096/fj.09-153718
    Complete structured claim and evidence

  2. Chdh deletion lowered testicular betaine while choline and phosphocholine increased.

    Experimental mouse Chdh-null genotype → Mouse testicular betaine concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/choline-research/20371614.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48", "start_char": 0, "end_char": 1334, "text_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48"}
    experimental_model
    Chdh-null mouse genetics and sperm biochemical assays
    exposure
    Chdh deletion versus wild type
    limitations
    Loss of an enzyme is not the same exposure as low dietary choline; mouse fertility results are not a human diagnostic rule. The 2018 correction replaces the original knockout exon diagram: exons 1–6 and much of exon 7 were deleted, not only exons 1–3 (PMID 29698116; doi:10.1096/fj.09-153718ERR).
    nutrient_topic
    Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
    organism
    Mouse
    plain_language
    Choline accumulated upstream while a downstream product fell.
    primary_references
    [choline-p20371614] Deletion of murine choline dehydrogenase results in diminished sperm motility. (2010). https://pubmed.ncbi.nlm.nih.gov/20371614/ DOI: 10.1096/fj.09-153718
    tissue_or_cell_type
    Testis and sperm mitochondria
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 568–579

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Chdh-null mouse genetics and sperm biochemical assays · source_derived_draft · unverified_draft

    ### choline-chdh-betaine Chdh deletion lowered testicular betaine while choline and phosphocholine increased. Condition category: machinery_impairment nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Choline accumulated upstream while a downstream product fell. organism: Mouse tissue_or_cell_type: Testis and sperm mitochondria experimental_model: Chdh-null mouse genetics and sperm biochemical assays limitations: Loss of an enzyme is not the same exposure as low dietary choline; mouse fertility results are not a human diagnostic rule. The 2018 correction replaces the original knockout exon diagram: exons 1–6 and much of exon 7 were deleted, not only exons 1–3 (PMID 29698116; doi:10.1096/fj.09-153718ERR). exposure: Chdh deletion versus wild type evidence_span: {"source_cache": "artifacts/choline-research/20371614.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48", "start_char": 0, "end_char": 1334, "text_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48"} [choline-p20371614] Deletion of murine choline dehydrogenase results in diminished sperm motility. (2010). https://pubmed.ncbi.nlm.nih.gov/20371614/ DOI: 10.1096/fj.09-153718
    Complete structured claim and evidence

  3. Chdh-null males produced comparable amounts of sperm but had diminished sperm motility.

    Experimental mouse Chdh-null genotype → Mouse sperm motility source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/choline-research/20371614.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48", "start_char": 0, "end_char": 1334, "text_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48"}
    experimental_model
    Chdh-null mouse genetics and sperm biochemical assays
    exposure
    Chdh deletion versus wild type
    limitations
    Loss of an enzyme is not the same exposure as low dietary choline; mouse fertility results are not a human diagnostic rule. The 2018 correction replaces the original knockout exon diagram: exons 1–6 and much of exon 7 were deleted, not only exons 1–3 (PMID 29698116; doi:10.1096/fj.09-153718ERR).
    nutrient_topic
    Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
    organism
    Mouse
    plain_language
    Sperm number and sperm movement were different outcomes.
    primary_references
    [choline-p20371614] Deletion of murine choline dehydrogenase results in diminished sperm motility. (2010). https://pubmed.ncbi.nlm.nih.gov/20371614/ DOI: 10.1096/fj.09-153718
    tissue_or_cell_type
    Testis and sperm mitochondria
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 594–605

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Chdh-null mouse genetics and sperm biochemical assays · source_derived_draft · unverified_draft

    ### choline-chdh-motility Chdh-null males produced comparable amounts of sperm but had diminished sperm motility. Condition category: machinery_impairment nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Sperm number and sperm movement were different outcomes. organism: Mouse tissue_or_cell_type: Testis and sperm mitochondria experimental_model: Chdh-null mouse genetics and sperm biochemical assays limitations: Loss of an enzyme is not the same exposure as low dietary choline; mouse fertility results are not a human diagnostic rule. The 2018 correction replaces the original knockout exon diagram: exons 1–6 and much of exon 7 were deleted, not only exons 1–3 (PMID 29698116; doi:10.1096/fj.09-153718ERR). exposure: Chdh deletion versus wild type evidence_span: {"source_cache": "artifacts/choline-research/20371614.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48", "start_char": 0, "end_char": 1334, "text_sha256": "dce0c14d2eb09194040087e691053960d9e4f477a49099cdd9482ad9ab38dc48"} [choline-p20371614] Deletion of murine choline dehydrogenase results in diminished sperm motility. (2010). https://pubmed.ncbi.nlm.nih.gov/20371614/ DOI: 10.1096/fj.09-153718
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards