Component
Mouse object-location memory after injected sodium butyrate
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Hippocampal Bdnf siRNA blocked the memory-enabling effect of post-training sodium butyrate in the mouse task.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Mouse hippocampal siRNA and object-location memory assay.
- limitations
- Task- and intervention-specific; not a universal mechanism for every memory effect of butyrate.
- nutrient_topic
- Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
- plain_language
- Reducing a neural growth-factor signal removed the measured benefit.
- primary_references
- Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23615664/ · DOI 10.1038/npp.2013.104
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 630–636
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse hippocampal siRNA and object-location memory assay. · source_derived_draft · unverified_draft
## butyrate-bdnf-knockdown Reducing a neural growth-factor signal removed the measured benefit. Hippocampal Bdnf siRNA blocked the memory-enabling effect of post-training sodium butyrate in the mouse task. Model: Mouse hippocampal siRNA and object-location memory assay. Limitations: Task- and intervention-specific; not a universal mechanism for every memory effect of butyrate. Evidence access: Primary abstract Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23615664/ · DOI 10.1038/npp.2013.104
Complete structured claim and evidencePost-training sodium butyrate injection enabled 24-hour object-location memory after otherwise subthreshold training in mice, with increased hippocampal Bdnf transcripts.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse behavioral and hippocampal transcription experiments.
- limitations
- Injected pharmacological exposure does not establish that ordinary microbial production or oral supplements improve human memory.
- nutrient_topic
- Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
- plain_language
- Injected treatment changed a learning response in mice.
- primary_references
- Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23615664/ · DOI 10.1038/npp.2013.104
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 622–628
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse behavioral and hippocampal transcription experiments. · source_derived_draft · unverified_draft
## butyrate-brain-memory Injected treatment changed a learning response in mice. Post-training sodium butyrate injection enabled 24-hour object-location memory after otherwise subthreshold training in mice, with increased hippocampal Bdnf transcripts. Model: Mouse behavioral and hippocampal transcription experiments. Limitations: Injected pharmacological exposure does not establish that ordinary microbial production or oral supplements improve human memory. Evidence access: Primary abstract Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23615664/ · DOI 10.1038/npp.2013.104
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.