Component

Mouse macrophage bacterial phagocytosis in the apigenin study

Mouse macrophage bacterial phagocytosis in the apigenin study

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Fgr knockdown raised baseline macrophage phagocytosis and blunted the additional response to apigenin.

    Apigenin → Mouse macrophage bacterial phagocytosis in the apigenin study Recorded from sourceungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
    experimental_condition
    Apigenin response with control knockdown Apigenin with Fgr knockdown · Apigenin Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Apigenin response with control knockdown knocked down · Mouse tyrosine-protein kinase Fgr Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "Apigenin with Fgr knockdown", "comparator": "Apigenin response with control knockdown", "endpoint": "Fgr knockdown raised baseline macrophage phagocytosis and blunted the additional response to apigenin.", "effect_direction": "mixed", "combination": "joint", "conditions": [{"entity_slug": "apigenin", "state": "Apigenin with Fgr knockdown"}, {"entity_slug": "mouse-fgr", "state": "knocked down"}]} Explicit extracted experimental comparison; recorded from source.
    experimental_model
    Mouse macrophage knockdown; Fgr overexpression also weakened the apigenin response.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    Fgr knockdown raised baseline macrophage phagocytosis and blunted the additional response to apigenin.
    primary_references
    Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008
    source_locator
    Reviewed reference api-fgr-knockdown; Baseline and incremental effects must be separated. Epistasis supports involvement without proving a single exclusive target.
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 456–462

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Mouse macrophage knockdown; Fgr overexpression also weakened the apigenin response. · Recorded from source · Recorded from source

    ### api-fgr-knockdown Fgr knockdown raised baseline macrophage phagocytosis and blunted the additional response to apigenin. Baseline and incremental effects must be separated. Epistasis supports involvement without proving a single exclusive target. Model and exposure: Mouse macrophage knockdown; Fgr overexpression also weakened the apigenin response. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | 2025 | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
    Complete structured claim and evidence

  2. Apigenin increased E. coli bioparticle uptake and bacterial phagocytosis in mouse macrophage experiments.

    Apigenin → Mouse macrophage bacterial phagocytosis in the apigenin study Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
    experimental_contrast
    {"intervention": "Apigenin before bacterial challenge", "comparator": "DMSO before the same challenge", "endpoint": "Apigenin increased E. coli bioparticle uptake and bacterial phagocytosis in mouse macrophage experiments.", "effect_direction": "increase", "combination": "single", "conditions": []} Explicit extracted experimental comparison; recorded from source.
    experimental_model
    Mouse peritoneal macrophages and BMDMs; typical cell exposure 20 micromolar, 3 hours.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    Apigenin increased E. coli bioparticle uptake and bacterial phagocytosis in mouse macrophage experiments.
    primary_references
    Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008
    source_locator
    Reviewed reference api-mouse-phagocytosis; Neutrophil phagocytosis and direct E. coli growth did not show the same response.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 440–446

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Mouse peritoneal macrophages and BMDMs; typical cell exposure 20 micromolar, 3 hours. · Recorded from source · Recorded from source

    ### api-mouse-phagocytosis Apigenin increased E. coli bioparticle uptake and bacterial phagocytosis in mouse macrophage experiments. Neutrophil phagocytosis and direct E. coli growth did not show the same response. Model and exposure: Mouse peritoneal macrophages and BMDMs; typical cell exposure 20 micromolar, 3 hours. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense. | 2025 | https://pubmed.ncbi.nlm.nih.gov/39792643/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11948050/ | https://doi.org/10.1002/advs.202411008 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.