Component

Mouse Abcg2 / Bcrp1

Mouse ATP-binding cassette riboflavin efflux transporter.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Intestinal ABCG2 protein increased in mangiferin-treated hyperuricemic mice.

    Mangiferin → Mouse Abcg2 / Bcrp1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/mangiferin-research/32827538.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "96aea91b79bcbc9d1f63f83c0bda025138e3b97f3f7657b56149c9cc3e0e5958", "start_char": 0, "end_char": 1796, "text_sha256": "96aea91b79bcbc9d1f63f83c0bda025138e3b97f3f7657b56149c9cc3e0e5958"}
    experimental_model
    Rodent intestinal-loop secretion/absorption experiments
    exposure
    Mangiferin in normal and hyperuricemic loop experiments
    limitations
    Expression association does not establish direct binding; intestinal effects need not mirror kidney effects.
    nutrient_topic
    Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
    organism
    Mice for secretion/proteins; rats for absorption
    plain_language
    A shared drug and metabolite transporter changed in this tissue.
    primary_references
    [mangiferin-p32827538] Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. (2020). https://pubmed.ncbi.nlm.nih.gov/32827538/ DOI: 10.1016/j.ejphar.2020.173490
    tissue_or_cell_type
    Intestine

    Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1108–1119

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rodent intestinal-loop secretion/absorption experiments · source_derived_draft · unverified_draft

    ### mangiferin-intestinal-abcg2 Intestinal ABCG2 protein increased in mangiferin-treated hyperuricemic mice. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A shared drug and metabolite transporter changed in this tissue. organism: Mice for secretion/proteins; rats for absorption tissue_or_cell_type: Intestine experimental_model: Rodent intestinal-loop secretion/absorption experiments limitations: Expression association does not establish direct binding; intestinal effects need not mirror kidney effects. exposure: Mangiferin in normal and hyperuricemic loop experiments evidence_span: {"source_cache": "artifacts/mangiferin-research/32827538.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "96aea91b79bcbc9d1f63f83c0bda025138e3b97f3f7657b56149c9cc3e0e5958", "start_char": 0, "end_char": 1796, "text_sha256": "96aea91b79bcbc9d1f63f83c0bda025138e3b97f3f7657b56149c9cc3e0e5958"} [mangiferin-p32827538] Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. (2020). https://pubmed.ncbi.nlm.nih.gov/32827538/ DOI: 10.1016/j.ejphar.2020.173490
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Curcumin increased sulfasalazine AUC about eightfold in wild-type mice but not in Bcrp-null mice.

    Experimental mouse Abcg2 knockout → Mouse sulfasalazine plasma exposure source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/curcumin-research/22300367.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a8ec64e7dff4a52838fa067fdc9418ee3ebe768c4a4d53629bd84f9f0ffe67fe", "start_char": 0, "end_char": 1713, "text_sha256": "a8ec64e7dff4a52838fa067fdc9418ee3ebe768c4a4d53629bd84f9f0ffe67fe"}
    experimental_model
    Human pharmacokinetics, transporter vesicles and mouse knockout experiment
    exposure
    Human: curcumin 2 g before sulfasalazine 100 micrograms or 2 g; eight participants. Mouse: 300-400 mg/kg curcumin
    limitations
    Small dose- and formulation-specific drug study. Transporter inference is supported by separate assays, not a universal effect on every BCRP substrate.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Mus musculus
    plain_language
    Removing the transporter removed this interaction in the mouse experiment.
    primary_references
    [curcumin-p22300367] Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. (2012). https://pubmed.ncbi.nlm.nih.gov/22300367/ DOI: 10.1111/j.1476-5381.2012.01887.x
    tissue_or_cell_type
    Plasma pharmacokinetics
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 814–825

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human pharmacokinetics, transporter vesicles and mouse knockout experiment · source_derived_draft · unverified_draft

    ### curcumin-bcrp-loss Curcumin increased sulfasalazine AUC about eightfold in wild-type mice but not in Bcrp-null mice. Condition category: machinery_impairment nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing the transporter removed this interaction in the mouse experiment. organism: Mus musculus tissue_or_cell_type: Plasma pharmacokinetics experimental_model: Human pharmacokinetics, transporter vesicles and mouse knockout experiment limitations: Small dose- and formulation-specific drug study. Transporter inference is supported by separate assays, not a universal effect on every BCRP substrate. exposure: Human: curcumin 2 g before sulfasalazine 100 micrograms or 2 g; eight participants. Mouse: 300-400 mg/kg curcumin evidence_span: {"source_cache": "artifacts/curcumin-research/22300367.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a8ec64e7dff4a52838fa067fdc9418ee3ebe768c4a4d53629bd84f9f0ffe67fe", "start_char": 0, "end_char": 1713, "text_sha256": "a8ec64e7dff4a52838fa067fdc9418ee3ebe768c4a4d53629bd84f9f0ffe67fe"} [curcumin-p22300367] Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. (2012). https://pubmed.ncbi.nlm.nih.gov/22300367/ DOI: 10.1111/j.1476-5381.2012.01887.x
    Complete structured claim and evidence

  2. Milk FAD concentrations were unchanged in Abcg2-null dams, demonstrating an ABCG2-independent route for milk vitamin B2 equivalents.

    Abcg2-null mouse genotype → FAD secretion into milk source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_location
    Figure 5A and discussion
    experimental_model
    Lactating knockout/wild-type mouse comparison with HPLC
    exposure
    Standard-chow lactating knockout and wild-type mice.
    limitations
    The independent FAD secretion machinery was not identified.
    nutrient_topic
    Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
    organism
    Mus musculus
    plain_language
    Milk retains another flavin supply route when free-riboflavin secretion falls.
    primary_references
    [transport-abcg2-2007] Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. (2007). https://pmc.ncbi.nlm.nih.gov/articles/PMC1800714/ DOI: 10.1128/MCB.01621-06
    tissue_or_cell_type
    Mammary milk
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 557–568

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lactating knockout/wild-type mouse comparison with HPLC · source_derived_draft · unverified_draft

    ### transport-abcg2-independent-milk-fad Milk FAD concentrations were unchanged in Abcg2-null dams, demonstrating an ABCG2-independent route for milk vitamin B2 equivalents. Condition category: machinery_impairment nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Milk retains another flavin supply route when free-riboflavin secretion falls. organism: Mus musculus tissue_or_cell_type: Mammary milk experimental_model: Lactating knockout/wild-type mouse comparison with HPLC limitations: The independent FAD secretion machinery was not identified. exposure: Standard-chow lactating knockout and wild-type mice. evidence_location: Figure 5A and discussion [transport-abcg2-2007] Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. (2007). https://pmc.ncbi.nlm.nih.gov/articles/PMC1800714/ DOI: 10.1128/MCB.01621-06
    Complete structured claim and evidence

  3. Abcg2-null dams had approximately 63-fold lower free riboflavin in milk than wild type on standard chow.

    Abcg2-null mouse genotype → Riboflavin secretion into milk source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_location
    Figure 5A
    experimental_model
    Lactating knockout/wild-type mouse comparison with HPLC
    exposure
    Chow containing 12-14 mg/kg riboflavin; lactating dams.
    limitations
    Mouse result; magnitude depends on chow and lactation conditions.
    nutrient_topic
    Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
    organism
    Mus musculus
    plain_language
    ABCG2 normally makes a major contribution to riboflavin delivery into milk.
    primary_references
    [transport-abcg2-2007] Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. (2007). https://pmc.ncbi.nlm.nih.gov/articles/PMC1800714/ DOI: 10.1128/MCB.01621-06
    tissue_or_cell_type
    Mammary milk
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 544–555

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lactating knockout/wild-type mouse comparison with HPLC · source_derived_draft · unverified_draft

    ### transport-abcg2-milk-riboflavin Abcg2-null dams had approximately 63-fold lower free riboflavin in milk than wild type on standard chow. Condition category: machinery_impairment nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: ABCG2 normally makes a major contribution to riboflavin delivery into milk. organism: Mus musculus tissue_or_cell_type: Mammary milk experimental_model: Lactating knockout/wild-type mouse comparison with HPLC limitations: Mouse result; magnitude depends on chow and lactation conditions. exposure: Chow containing 12-14 mg/kg riboflavin; lactating dams. evidence_location: Figure 5A [transport-abcg2-2007] Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. (2007). https://pmc.ncbi.nlm.nih.gov/articles/PMC1800714/ DOI: 10.1128/MCB.01621-06
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards