Component
Abcg2-null mouse genotype
Bcrp1/Abcg2 knockout mouse used in milk secretion studies.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Milk FAD concentrations were unchanged in Abcg2-null dams, demonstrating an ABCG2-independent route for milk vitamin B2 equivalents.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_location
- Figure 5A and discussion
- experimental_model
- Lactating knockout/wild-type mouse comparison with HPLC
- exposure
- Standard-chow lactating knockout and wild-type mice.
- limitations
- The independent FAD secretion machinery was not identified.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Mus musculus
- plain_language
- Milk retains another flavin supply route when free-riboflavin secretion falls.
- primary_references
- [transport-abcg2-2007] Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. (2007). https://pmc.ncbi.nlm.nih.gov/articles/PMC1800714/ DOI: 10.1128/MCB.01621-06
- tissue_or_cell_type
- Mammary milk
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 557–568
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lactating knockout/wild-type mouse comparison with HPLC · source_derived_draft · unverified_draft
### transport-abcg2-independent-milk-fad Milk FAD concentrations were unchanged in Abcg2-null dams, demonstrating an ABCG2-independent route for milk vitamin B2 equivalents. Condition category: machinery_impairment nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Milk retains another flavin supply route when free-riboflavin secretion falls. organism: Mus musculus tissue_or_cell_type: Mammary milk experimental_model: Lactating knockout/wild-type mouse comparison with HPLC limitations: The independent FAD secretion machinery was not identified. exposure: Standard-chow lactating knockout and wild-type mice. evidence_location: Figure 5A and discussion [transport-abcg2-2007] Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. (2007). https://pmc.ncbi.nlm.nih.gov/articles/PMC1800714/ DOI: 10.1128/MCB.01621-06
Complete structured claim and evidenceAbcg2-null dams had approximately 63-fold lower free riboflavin in milk than wild type on standard chow.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_location
- Figure 5A
- experimental_model
- Lactating knockout/wild-type mouse comparison with HPLC
- exposure
- Chow containing 12-14 mg/kg riboflavin; lactating dams.
- limitations
- Mouse result; magnitude depends on chow and lactation conditions.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Mus musculus
- plain_language
- ABCG2 normally makes a major contribution to riboflavin delivery into milk.
- primary_references
- [transport-abcg2-2007] Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. (2007). https://pmc.ncbi.nlm.nih.gov/articles/PMC1800714/ DOI: 10.1128/MCB.01621-06
- tissue_or_cell_type
- Mammary milk
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 544–555
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Lactating knockout/wild-type mouse comparison with HPLC · source_derived_draft · unverified_draft
### transport-abcg2-milk-riboflavin Abcg2-null dams had approximately 63-fold lower free riboflavin in milk than wild type on standard chow. Condition category: machinery_impairment nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: ABCG2 normally makes a major contribution to riboflavin delivery into milk. organism: Mus musculus tissue_or_cell_type: Mammary milk experimental_model: Lactating knockout/wild-type mouse comparison with HPLC limitations: Mouse result; magnitude depends on chow and lactation conditions. exposure: Chow containing 12-14 mg/kg riboflavin; lactating dams. evidence_location: Figure 5A [transport-abcg2-2007] Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. (2007). https://pmc.ncbi.nlm.nih.gov/articles/PMC1800714/ DOI: 10.1128/MCB.01621-06
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.