Component

Mitochondrial creatine kinase family

Mitochondrial creatine kinase family. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The mitochondrial creatine kinase structure supported an octameric enzyme positioned to convert mitochondrially generated ATP into phosphocreatine.

    Mitochondrial creatine kinase family → Phosphocreatine source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/8692275.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dca64c2f8e71d91a83ba9bbcc8cc320c7c87e2239de6f07111efe0560ac061c6", "start_char": 0, "end_char": 1125, "text_sha256": "dca64c2f8e71d91a83ba9bbcc8cc320c7c87e2239de6f07111efe0560ac061c6"}
    experimental_model
    Mitochondrial creatine kinase crystal structure
    exposure
    Octamer architecture and electrostatic surface analysis
    limitations
    The abstract does not specify the organism; no human-specific structural assignment is made. Membrane binding interpretation accompanies structural data.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Mitochondrial creatine kinase preparation in the primary study
    plain_language
    Mitochondrial creatine kinase can load the phosphate carrier near the site of ATP production.
    primary_references
    [creatine-p8692275] Structure of mitochondrial creatine kinase. (1996). https://pubmed.ncbi.nlm.nih.gov/8692275/ DOI: 10.1038/381341a0
    tissue_or_cell_type
    Purified protein; mitochondrial membrane interface interpretation

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 360–371

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mitochondrial creatine kinase crystal structure · source_derived_draft · unverified_draft

    ### creatine-mitochondrial-ck-organization The mitochondrial creatine kinase structure supported an octameric enzyme positioned to convert mitochondrially generated ATP into phosphocreatine. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Mitochondrial creatine kinase can load the phosphate carrier near the site of ATP production. organism: Mitochondrial creatine kinase preparation in the primary study tissue_or_cell_type: Purified protein; mitochondrial membrane interface interpretation experimental_model: Mitochondrial creatine kinase crystal structure limitations: The abstract does not specify the organism; no human-specific structural assignment is made. Membrane binding interpretation accompanies structural data. exposure: Octamer architecture and electrostatic surface analysis evidence_span: {"source_cache": "artifacts/creatine-research/8692275.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dca64c2f8e71d91a83ba9bbcc8cc320c7c87e2239de6f07111efe0560ac061c6", "start_char": 0, "end_char": 1125, "text_sha256": "dca64c2f8e71d91a83ba9bbcc8cc320c7c87e2239de6f07111efe0560ac061c6"} [creatine-p8692275] Structure of mitochondrial creatine kinase. (1996). https://pubmed.ncbi.nlm.nih.gov/8692275/ DOI: 10.1038/381341a0
    Complete structured claim and evidence

  2. Mitochondrial creatine kinase selectively recruited cardiolipin and promoted lipid clustering in the tested reconstituted membranes.

    Mitochondrial creatine kinase family → Cardiolipin enrichment and clustering in a membrane source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/19289067.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3880cefa5c138a1e112b50ad2d734e8f38c70da3a545aff80969e7aa1e9a5666", "start_char": 0, "end_char": 1484, "text_sha256": "3880cefa5c138a1e112b50ad2d734e8f38c70da3a545aff80969e7aa1e9a5666"}
    experimental_model
    Protein–lipid monolayer and mixed-membrane experiments
    exposure
    Creatine kinase added to cardiolipin or mixed phospholipid films
    limitations
    Mitochondrial CK family record; the specific human isoform is not assigned from this abstract. Reconstituted membrane experiment; no human outcome.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Mitochondrial creatine kinase in reconstituted lipid systems
    plain_language
    The enzyme can help organize the membrane lipids around it.
    primary_references
    [creatine-p19289067] Mitochondrial creatine kinase binding to phospholipid monolayers induces cardiolipin segregation. (2009). https://pubmed.ncbi.nlm.nih.gov/19289067/ DOI: 10.1016/j.bpj.2008.12.3911
    tissue_or_cell_type
    Synthetic cardiolipin-containing membranes

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 373–384

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Protein–lipid monolayer and mixed-membrane experiments · source_derived_draft · unverified_draft

    ### creatine-mtck-cardiolipin Mitochondrial creatine kinase selectively recruited cardiolipin and promoted lipid clustering in the tested reconstituted membranes. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The enzyme can help organize the membrane lipids around it. organism: Mitochondrial creatine kinase in reconstituted lipid systems tissue_or_cell_type: Synthetic cardiolipin-containing membranes experimental_model: Protein–lipid monolayer and mixed-membrane experiments limitations: Mitochondrial CK family record; the specific human isoform is not assigned from this abstract. Reconstituted membrane experiment; no human outcome. exposure: Creatine kinase added to cardiolipin or mixed phospholipid films evidence_span: {"source_cache": "artifacts/creatine-research/19289067.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3880cefa5c138a1e112b50ad2d734e8f38c70da3a545aff80969e7aa1e9a5666", "start_char": 0, "end_char": 1484, "text_sha256": "3880cefa5c138a1e112b50ad2d734e8f38c70da3a545aff80969e7aa1e9a5666"} [creatine-p19289067] Mitochondrial creatine kinase binding to phospholipid monolayers induces cardiolipin segregation. (2009). https://pubmed.ncbi.nlm.nih.gov/19289067/ DOI: 10.1016/j.bpj.2008.12.3911
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Creatine enhanced respiration in beige-fat mitochondria when ADP was limiting, and cold exposure stimulated mitochondrial creatine kinase activity and induced coordinated expression of creatine metabolism genes in murine beige fat.

    Creatine → The futile creatine substrate cycle in thermogenic adipocytes source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/26496606.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f2d52dfe935e633b9d69280d707a124080d6f6c4d650f94bc8cf6a00f26e43e7", "start_char": 0, "end_char": 1097, "text_sha256": "f2d52dfe935e633b9d69280d707a124080d6f6c4d650f94bc8cf6a00f26e43e7"}
    experimental_model
    Quantitative mitochondrial proteomics of brown and beige fat with pharmacological creatine reduction
    exposure
    Cold exposure, beta-3 agonist administration, and creatine depletion
    limitations
    Identifies a UCP1-independent route. Pharmacological creatine reduction is a blunt tool, and the compensatory induction in UCP1-deficient mice is an expression finding.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Mouse
    plain_language
    A second heat route runs a creatine cycle that burns energy on purpose.
    primary_references
    [cold-p26496606] A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. (2015). https://pubmed.ncbi.nlm.nih.gov/26496606/ DOI: 10.1016/j.cell.2015.09.035
    tissue_or_cell_type
    Beige and brown adipose tissue

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 442–453

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Quantitative mitochondrial proteomics of brown and beige fat with pharmacological creatine reduction · source_derived_draft · unverified_draft

    ### cold-creatine-cycle Creatine enhanced respiration in beige-fat mitochondria when ADP was limiting, and cold exposure stimulated mitochondrial creatine kinase activity and induced coordinated expression of creatine metabolism genes in murine beige fat. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: A second heat route runs a creatine cycle that burns energy on purpose. organism: Mouse tissue_or_cell_type: Beige and brown adipose tissue experimental_model: Quantitative mitochondrial proteomics of brown and beige fat with pharmacological creatine reduction limitations: Identifies a UCP1-independent route. Pharmacological creatine reduction is a blunt tool, and the compensatory induction in UCP1-deficient mice is an expression finding. exposure: Cold exposure, beta-3 agonist administration, and creatine depletion evidence_span: {"source_cache": "artifacts/cold-research/26496606.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f2d52dfe935e633b9d69280d707a124080d6f6c4d650f94bc8cf6a00f26e43e7", "start_char": 0, "end_char": 1097, "text_sha256": "f2d52dfe935e633b9d69280d707a124080d6f6c4d650f94bc8cf6a00f26e43e7"} [cold-p26496606] A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. (2015). https://pubmed.ncbi.nlm.nih.gov/26496606/ DOI: 10.1016/j.cell.2015.09.035
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards