{"id":"73cafbd0-2ee4-527f-b7e3-f0b31ee48326","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-mtck-cardiolipin","predicate":"associated_with","statement":"Mitochondrial creatine kinase selectively recruited cardiolipin and promoted lipid clustering in the tested reconstituted membranes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bf23d973-0753-5e34-af43-6ea43212309a","mechanism_event_label":"The enzyme can help organize the membrane lipids around it.","subject":{"id":"452f03f7-730f-56c7-aa6e-63ab20ce3ce3","slug":"mitochondrial-creatine-kinases","display_name":"Mitochondrial creatine kinase family","entity_type_key":"protein_family"},"object":{"id":"08cb11ab-e024-5770-9dd2-b14b86e5e4cf","slug":"cardiolipin-clustering","display_name":"Cardiolipin enrichment and clustering in a membrane","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bf23d973-0753-5e34-af43-6ea43212309a","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-mtck-cardiolipin-event","event_type":"biochemical_relationship","label":"The enzyme can help organize the membrane lipids around it.","description":"Mitochondrial creatine kinase selectively recruited cardiolipin and promoted lipid clustering in the tested reconstituted membranes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1a3cdf66-fd06-53ed-af0c-cbb460cdcecc","slug":"cardiolipin","display_name":"Cardiolipin","entity_type_key":"chemical_species"},"role":"membrane_lipid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"452f03f7-730f-56c7-aa6e-63ab20ce3ce3","slug":"mitochondrial-creatine-kinases","display_name":"Mitochondrial creatine kinase family","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"08cb11ab-e024-5770-9dd2-b14b86e5e4cf","slug":"cardiolipin-clustering","display_name":"Cardiolipin enrichment and clustering in a membrane","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/19289067.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3880cefa5c138a1e112b50ad2d734e8f38c70da3a545aff80969e7aa1e9a5666\", \"start_char\": 0, \"end_char\": 1484, \"text_sha256\": \"3880cefa5c138a1e112b50ad2d734e8f38c70da3a545aff80969e7aa1e9a5666\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein–lipid monolayer and mixed-membrane experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Creatine kinase added to cardiolipin or mixed phospholipid films","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mitochondrial CK family record; the specific human isoform is not assigned from this abstract. Reconstituted membrane experiment; no human outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mitochondrial creatine kinase in reconstituted lipid systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The enzyme can help organize the membrane lipids around it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p19289067] Mitochondrial creatine kinase binding to phospholipid monolayers induces cardiolipin segregation. (2009). https://pubmed.ncbi.nlm.nih.gov/19289067/ DOI: 10.1016/j.bpj.2008.12.3911","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Synthetic cardiolipin-containing membranes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c40b81d8-38b5-5da3-81b9-4b6d43065a3a","evidence_kind":"source_excerpt","locator":"Lines 373-384","start_line":373,"end_line":384,"excerpt":"### creatine-mtck-cardiolipin\nMitochondrial creatine kinase selectively recruited cardiolipin and promoted lipid clustering in the tested reconstituted membranes.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The enzyme can help organize the membrane lipids around it.\norganism: Mitochondrial creatine kinase in reconstituted lipid systems\ntissue_or_cell_type: Synthetic cardiolipin-containing membranes\nexperimental_model: Protein–lipid monolayer and mixed-membrane experiments\nlimitations: Mitochondrial CK family record; the specific human isoform is not assigned from this abstract. Reconstituted membrane experiment; no human outcome.\nexposure: Creatine kinase added to cardiolipin or mixed phospholipid films\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/19289067.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3880cefa5c138a1e112b50ad2d734e8f38c70da3a545aff80969e7aa1e9a5666\", \"start_char\": 0, \"end_char\": 1484, \"text_sha256\": \"3880cefa5c138a1e112b50ad2d734e8f38c70da3a545aff80969e7aa1e9a5666\"}\n[creatine-p19289067] Mitochondrial creatine kinase binding to phospholipid monolayers induces cardiolipin segregation. (2009). https://pubmed.ncbi.nlm.nih.gov/19289067/ DOI: 10.1016/j.bpj.2008.12.3911","model_system":"Protein–lipid monolayer and mixed-membrane experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [creatine-p19289067] Mitochondrial creatine kinase binding to phospholipid monolayers induces cardiolipin segregation. (2009). https://pubmed.ncbi.nlm.nih.gov/19289067/ DOI: 10.1016/j.bpj.2008.12.3911","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70358046-c5c3-5e9a-9fc9-eb01c3fff88b","stable_key":"import-44737fa3-b335-53f4-a644-b9878d4416ac","title":"Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"548237d3e98a73a7dc02181807921fdd8b902adcee46248792258a761593eda9","revision_id":"88738255-8028-52fb-9c12-0fe92d8ce367","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}