Component
Mitochondrial calcium efflux
Mitochondrial calcium efflux. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
NCLX overexpression increased sodium-dependent mitochondrial calcium efflux; silencing reduced it and heterologous rescue restored it.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/sodium-research/20018762.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8594465b44cbb04ed3a631d5dae19959e7c0494a86537d6a60d33d6db1821831", "start_char": 0, "end_char": 1085, "text_sha256": "8594465b44cbb04ed3a631d5dae19959e7c0494a86537d6a60d33d6db1821831"}
- experimental_model
- Overexpression, siRNA, rescue, mutant and fluorescent ion-imaging experiments
- exposure
- NCLX abundance, inactive mutant and ion substitutions
- limitations
- Supports molecular identification in these assays. Protein species and construct details must be taken from the original methods; not evidence for raising dietary sodium.
- nutrient_topic
- Sodium research collection; topical membership is not evidence of a direct dietary effect. · Sodium
- organism
- Mammalian cultured-cell preparations
- plain_language
- A mitochondrial exchanger connects sodium movement with calcium removal.
- primary_references
- [sodium-p20018762] NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. (2010). https://pubmed.ncbi.nlm.nih.gov/20018762/ DOI: 10.1073/pnas.0908099107
- tissue_or_cell_type
- Mitochondrial cristae
Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17) · lines 733–744
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Overexpression, siRNA, rescue, mutant and fluorescent ion-imaging experiments · source_derived_draft · unverified_draft
### sodium-nclx-efflux NCLX overexpression increased sodium-dependent mitochondrial calcium efflux; silencing reduced it and heterologous rescue restored it. Condition category: normal nutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect. plain_language: A mitochondrial exchanger connects sodium movement with calcium removal. organism: Mammalian cultured-cell preparations tissue_or_cell_type: Mitochondrial cristae experimental_model: Overexpression, siRNA, rescue, mutant and fluorescent ion-imaging experiments limitations: Supports molecular identification in these assays. Protein species and construct details must be taken from the original methods; not evidence for raising dietary sodium. exposure: NCLX abundance, inactive mutant and ion substitutions evidence_span: {"source_cache": "artifacts/sodium-research/20018762.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8594465b44cbb04ed3a631d5dae19959e7c0494a86537d6a60d33d6db1821831", "start_char": 0, "end_char": 1085, "text_sha256": "8594465b44cbb04ed3a631d5dae19959e7c0494a86537d6a60d33d6db1821831"} [sodium-p20018762] NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. (2010). https://pubmed.ncbi.nlm.nih.gov/20018762/ DOI: 10.1073/pnas.0908099107
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.