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Protein species and construct details must be taken from the original methods; not evidence for raising dietary sodium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mammalian cultured-cell preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A mitochondrial exchanger connects sodium movement with calcium removal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p20018762] NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. (2010). https://pubmed.ncbi.nlm.nih.gov/20018762/ DOI: 10.1073/pnas.0908099107","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial cristae","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"240ea406-e7b7-5c6b-a6e7-d431d58b44a8","evidence_kind":"source_excerpt","locator":"Lines 733-744","start_line":733,"end_line":744,"excerpt":"### sodium-nclx-efflux\nNCLX overexpression increased sodium-dependent mitochondrial calcium efflux; silencing reduced it and heterologous rescue restored it.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A mitochondrial exchanger connects sodium movement with calcium removal.\norganism: Mammalian cultured-cell preparations\ntissue_or_cell_type: Mitochondrial cristae\nexperimental_model: Overexpression, siRNA, rescue, mutant and fluorescent ion-imaging experiments\nlimitations: Supports molecular identification in these assays. Protein species and construct details must be taken from the original methods; not evidence for raising dietary sodium.\nexposure: NCLX abundance, inactive mutant and ion substitutions\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/20018762.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8594465b44cbb04ed3a631d5dae19959e7c0494a86537d6a60d33d6db1821831\", \"start_char\": 0, \"end_char\": 1085, \"text_sha256\": \"8594465b44cbb04ed3a631d5dae19959e7c0494a86537d6a60d33d6db1821831\"}\n[sodium-p20018762] NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. 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