Component
Glomerular filtration rate measured by tracer clearance
Glomerular filtration rate measured by tracer clearance. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Creatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in postmenopausal women.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/creatine-research/21574777.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4f5e67ad2a24e51cb17b0a014373841762659f8c1801dd8ae65d4917123cbbb4", "start_char": 0, "end_char": 693, "text_sha256": "4f5e67ad2a24e51cb17b0a014373841762659f8c1801dd8ae65d4917123cbbb4"}
- experimental_model
- Randomized placebo-controlled trial with measured 51Cr-EDTA clearance
- exposure
- 20 g/day for one week then 5 g/day through 12 weeks
- limitations
- No significant measured-GFR effect over 12 weeks; this does not establish safety in advanced kidney disease, all doses or lifelong exposure.
- nutrient_topic
- Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
- organism
- Postmenopausal women
- plain_language
- The study measured filtration directly rather than relying only on a creatinine-based estimate.
- primary_references
- [creatine-p21574777] Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women. (2011). https://pubmed.ncbi.nlm.nih.gov/21574777/ DOI: 10.1139/h11-014
- tissue_or_cell_type
- Kidney function
Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1075–1086
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled trial with measured 51Cr-EDTA clearance · source_derived_draft · unverified_draft
### creatine-measured-gfr-21574777 Creatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in postmenopausal women. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The study measured filtration directly rather than relying only on a creatinine-based estimate. organism: Postmenopausal women tissue_or_cell_type: Kidney function experimental_model: Randomized placebo-controlled trial with measured 51Cr-EDTA clearance limitations: No significant measured-GFR effect over 12 weeks; this does not establish safety in advanced kidney disease, all doses or lifelong exposure. exposure: 20 g/day for one week then 5 g/day through 12 weeks evidence_span: {"source_cache": "artifacts/creatine-research/21574777.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4f5e67ad2a24e51cb17b0a014373841762659f8c1801dd8ae65d4917123cbbb4", "start_char": 0, "end_char": 693, "text_sha256": "4f5e67ad2a24e51cb17b0a014373841762659f8c1801dd8ae65d4917123cbbb4"} [creatine-p21574777] Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women. (2011). https://pubmed.ncbi.nlm.nih.gov/21574777/ DOI: 10.1139/h11-014
Complete structured claim and evidenceCreatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in healthy resistance-trained people consuming at least 1.2 g protein/kg/day.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/creatine-research/23680457.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "00d1d37c5f4c752fba7ffa6b1c837cd4b48e6739ca05f815df3180baa2bf3193", "start_char": 0, "end_char": 1412, "text_sha256": "00d1d37c5f4c752fba7ffa6b1c837cd4b48e6739ca05f815df3180baa2bf3193"}
- experimental_model
- Randomized placebo-controlled trial with measured 51Cr-EDTA clearance
- exposure
- 20 g/day for five days then 5 g/day through 12 weeks
- limitations
- No significant measured-GFR effect over 12 weeks; this does not establish safety in advanced kidney disease, all doses or lifelong exposure.
- nutrient_topic
- Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
- organism
- Healthy resistance-trained people consuming at least 1.2 g protein/kg/day
- plain_language
- The study measured filtration directly rather than relying only on a creatinine-based estimate.
- primary_references
- [creatine-p23680457] Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? (2013). https://pubmed.ncbi.nlm.nih.gov/23680457/ DOI: 10.1186/1550-2783-10-26
- tissue_or_cell_type
- Kidney function
Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1088–1099
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled trial with measured 51Cr-EDTA clearance · source_derived_draft · unverified_draft
### creatine-measured-gfr-23680457 Creatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in healthy resistance-trained people consuming at least 1.2 g protein/kg/day. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The study measured filtration directly rather than relying only on a creatinine-based estimate. organism: Healthy resistance-trained people consuming at least 1.2 g protein/kg/day tissue_or_cell_type: Kidney function experimental_model: Randomized placebo-controlled trial with measured 51Cr-EDTA clearance limitations: No significant measured-GFR effect over 12 weeks; this does not establish safety in advanced kidney disease, all doses or lifelong exposure. exposure: 20 g/day for five days then 5 g/day through 12 weeks evidence_span: {"source_cache": "artifacts/creatine-research/23680457.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "00d1d37c5f4c752fba7ffa6b1c837cd4b48e6739ca05f815df3180baa2bf3193", "start_char": 0, "end_char": 1412, "text_sha256": "00d1d37c5f4c752fba7ffa6b1c837cd4b48e6739ca05f815df3180baa2bf3193"} [creatine-p23680457] Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? (2013). https://pubmed.ncbi.nlm.nih.gov/23680457/ DOI: 10.1186/1550-2783-10-26
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.