{"id":"9970c86c-dd40-5b2b-846c-084ad37c0955","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-measured-gfr-21574777","predicate":"did_not_significantly_change","statement":"Creatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in postmenopausal women.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"875fcaac-3561-5c30-9ae8-493e282d4a1a","mechanism_event_label":"The study measured filtration directly rather than relying only on a creatinine-based estimate.","subject":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"object":{"id":"ea433d62-df4e-5ca3-a260-60cef5f06c98","slug":"measured-glomerular-filtration","display_name":"Glomerular filtration rate measured by tracer clearance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"875fcaac-3561-5c30-9ae8-493e282d4a1a","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-measured-gfr-21574777-event","event_type":"observed_intervention","label":"The study measured filtration directly rather than relying only on a creatinine-based estimate.","description":"Creatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in postmenopausal women.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ea433d62-df4e-5ca3-a260-60cef5f06c98","slug":"measured-glomerular-filtration","display_name":"Glomerular filtration rate measured by tracer clearance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/21574777.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4f5e67ad2a24e51cb17b0a014373841762659f8c1801dd8ae65d4917123cbbb4\", \"start_char\": 0, \"end_char\": 693, \"text_sha256\": \"4f5e67ad2a24e51cb17b0a014373841762659f8c1801dd8ae65d4917123cbbb4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled trial with measured 51Cr-EDTA clearance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"20 g/day for one week then 5 g/day through 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No significant measured-GFR effect over 12 weeks; this does not establish safety in advanced kidney disease, all doses or lifelong exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Postmenopausal women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The study measured filtration directly rather than relying only on a creatinine-based estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p21574777] Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women. (2011). https://pubmed.ncbi.nlm.nih.gov/21574777/ DOI: 10.1139/h11-014","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney function","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a0cc8f31-8cfc-593d-8055-7f81846ef608","evidence_kind":"source_excerpt","locator":"Lines 1075-1086","start_line":1075,"end_line":1086,"excerpt":"### creatine-measured-gfr-21574777\nCreatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in postmenopausal women.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The study measured filtration directly rather than relying only on a creatinine-based estimate.\norganism: Postmenopausal women\ntissue_or_cell_type: Kidney function\nexperimental_model: Randomized placebo-controlled trial with measured 51Cr-EDTA clearance\nlimitations: No significant measured-GFR effect over 12 weeks; this does not establish safety in advanced kidney disease, all doses or lifelong exposure.\nexposure: 20 g/day for one week then 5 g/day through 12 weeks\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/21574777.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4f5e67ad2a24e51cb17b0a014373841762659f8c1801dd8ae65d4917123cbbb4\", \"start_char\": 0, \"end_char\": 693, \"text_sha256\": \"4f5e67ad2a24e51cb17b0a014373841762659f8c1801dd8ae65d4917123cbbb4\"}\n[creatine-p21574777] Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women. 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