{"id":"9a4f2c74-39d4-5cbd-ad87-bc5648e52317","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-measured-gfr-23680457","predicate":"did_not_significantly_change","statement":"Creatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in healthy resistance-trained people consuming at least 1.2 g protein/kg/day.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0825caea-0e77-5d81-888e-33c4fe1700c3","mechanism_event_label":"The study measured filtration directly rather than relying only on a creatinine-based estimate.","subject":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"object":{"id":"ea433d62-df4e-5ca3-a260-60cef5f06c98","slug":"measured-glomerular-filtration","display_name":"Glomerular filtration rate measured by tracer clearance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0825caea-0e77-5d81-888e-33c4fe1700c3","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-measured-gfr-23680457-event","event_type":"observed_intervention","label":"The study measured filtration directly rather than relying only on a creatinine-based estimate.","description":"Creatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in healthy resistance-trained people consuming at least 1.2 g protein/kg/day.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ea433d62-df4e-5ca3-a260-60cef5f06c98","slug":"measured-glomerular-filtration","display_name":"Glomerular filtration rate measured by tracer clearance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/23680457.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"00d1d37c5f4c752fba7ffa6b1c837cd4b48e6739ca05f815df3180baa2bf3193\", \"start_char\": 0, \"end_char\": 1412, \"text_sha256\": \"00d1d37c5f4c752fba7ffa6b1c837cd4b48e6739ca05f815df3180baa2bf3193\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled trial with measured 51Cr-EDTA clearance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"20 g/day for five days then 5 g/day through 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No significant measured-GFR effect over 12 weeks; this does not establish safety in advanced kidney disease, all doses or lifelong exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy resistance-trained people consuming at least 1.2 g protein/kg/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The study measured filtration directly rather than relying only on a creatinine-based estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p23680457] Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? (2013). https://pubmed.ncbi.nlm.nih.gov/23680457/ DOI: 10.1186/1550-2783-10-26","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney function","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bb748364-60c7-50dc-9ccf-d88a7debdcfc","evidence_kind":"source_excerpt","locator":"Lines 1088-1099","start_line":1088,"end_line":1099,"excerpt":"### creatine-measured-gfr-23680457\nCreatine supplementation did not significantly change tracer-measured glomerular filtration rate versus placebo over 12 weeks in healthy resistance-trained people consuming at least 1.2 g protein/kg/day.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The study measured filtration directly rather than relying only on a creatinine-based estimate.\norganism: Healthy resistance-trained people consuming at least 1.2 g protein/kg/day\ntissue_or_cell_type: Kidney function\nexperimental_model: Randomized placebo-controlled trial with measured 51Cr-EDTA clearance\nlimitations: No significant measured-GFR effect over 12 weeks; this does not establish safety in advanced kidney disease, all doses or lifelong exposure.\nexposure: 20 g/day for five days then 5 g/day through 12 weeks\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/23680457.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"00d1d37c5f4c752fba7ffa6b1c837cd4b48e6739ca05f815df3180baa2bf3193\", \"start_char\": 0, \"end_char\": 1412, \"text_sha256\": \"00d1d37c5f4c752fba7ffa6b1c837cd4b48e6739ca05f815df3180baa2bf3193\"}\n[creatine-p23680457] Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? 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