Component
Continuous mean post-ischaemic flow-mediated dilation
Continuous mean post-ischaemic flow-mediated dilation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
At one hour, continuous mean FMD increased by 0.47 and 0.65 percentage points with 450 and 900 mg, respectively.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chlorogenic_acid-research/27109860.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8", "start_char": 0, "end_char": 1585, "text_sha256": "e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8"}
- experimental_model
- Randomized-order acute crossover in 16 adults
- exposure
- 0, 450 or 900 mg purified 5-CGA; 200 mg epicatechin comparator; one-week spacing
- limitations
- Peak and continuous-mean FMD are different endpoints. Secondary positive findings must not replace the null peak response; no long-term vascular outcome was tested.
- nutrient_topic
- Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
- organism
- Human
- plain_language
- A different summary of the same vascular response showed a signal.
- primary_references
- [chlorogenic_acid-p27109860] Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. (2016). https://pubmed.ncbi.nlm.nih.gov/27109860/ DOI: 10.1039/c6fo00248j
- tissue_or_cell_type
- Brachial flow-mediated dilation and blood pressure
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 971–982
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized-order acute crossover in 16 adults · source_derived_draft · unverified_draft
### chlorogenic_acid-mean-fmd At one hour, continuous mean FMD increased by 0.47 and 0.65 percentage points with 450 and 900 mg, respectively. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A different summary of the same vascular response showed a signal. organism: Human tissue_or_cell_type: Brachial flow-mediated dilation and blood pressure experimental_model: Randomized-order acute crossover in 16 adults limitations: Peak and continuous-mean FMD are different endpoints. Secondary positive findings must not replace the null peak response; no long-term vascular outcome was tested. exposure: 0, 450 or 900 mg purified 5-CGA; 200 mg epicatechin comparator; one-week spacing evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/27109860.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8", "start_char": 0, "end_char": 1585, "text_sha256": "e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8"} [chlorogenic_acid-p27109860] Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. (2016). https://pubmed.ncbi.nlm.nih.gov/27109860/ DOI: 10.1039/c6fo00248j
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.