{"id":"08309bf1-5972-50e0-a968-ed208d3eb3a1","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-mean-fmd","predicate":"increased","statement":"At one hour, continuous mean FMD increased by 0.47 and 0.65 percentage points with 450 and 900 mg, respectively.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dc41a9c8-533f-5142-ad77-25f212ab0256","mechanism_event_label":"A different summary of the same vascular response showed a signal.","subject":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"object":{"id":"d863e7d0-0532-5134-9172-ab181eee4309","slug":"mean-postischemic-fmd","display_name":"Continuous mean post-ischaemic flow-mediated dilation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dc41a9c8-533f-5142-ad77-25f212ab0256","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-mean-fmd-event","event_type":"observed_intervention","label":"A different summary of the same vascular response showed a signal.","description":"At one hour, continuous mean FMD increased by 0.47 and 0.65 percentage points with 450 and 900 mg, respectively.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d863e7d0-0532-5134-9172-ab181eee4309","slug":"mean-postischemic-fmd","display_name":"Continuous mean post-ischaemic flow-mediated dilation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/27109860.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8\", \"start_char\": 0, \"end_char\": 1585, \"text_sha256\": \"e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized-order acute crossover in 16 adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"0, 450 or 900 mg purified 5-CGA; 200 mg epicatechin comparator; one-week spacing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Peak and continuous-mean FMD are different endpoints. Secondary positive findings must not replace the null peak response; no long-term vascular outcome was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A different summary of the same vascular response showed a signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p27109860] Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. (2016). https://pubmed.ncbi.nlm.nih.gov/27109860/ DOI: 10.1039/c6fo00248j","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brachial flow-mediated dilation and blood pressure","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fcc1c688-d836-5fb5-b7b1-67577e8779b8","evidence_kind":"source_excerpt","locator":"Lines 971-982","start_line":971,"end_line":982,"excerpt":"### chlorogenic_acid-mean-fmd\nAt one hour, continuous mean FMD increased by 0.47 and 0.65 percentage points with 450 and 900 mg, respectively.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A different summary of the same vascular response showed a signal.\norganism: Human\ntissue_or_cell_type: Brachial flow-mediated dilation and blood pressure\nexperimental_model: Randomized-order acute crossover in 16 adults\nlimitations: Peak and continuous-mean FMD are different endpoints. Secondary positive findings must not replace the null peak response; no long-term vascular outcome was tested.\nexposure: 0, 450 or 900 mg purified 5-CGA; 200 mg epicatechin comparator; one-week spacing\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/27109860.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8\", \"start_char\": 0, \"end_char\": 1585, \"text_sha256\": \"e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8\"}\n[chlorogenic_acid-p27109860] Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. 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