Component
Lysine chloride experimental supplement
Lysine chloride experimental supplement. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The pilot reported a mean serum chloride rise of 2.2 mmol/L after sodium-free lysine chloride supplementation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chloride-research/27507113.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "978879bf8054ce7c99ef939133966e618cc8030cb7bd624e250ce32002455927", "start_char": 0, "end_char": 2050, "text_sha256": "978879bf8054ce7c99ef939133966e618cc8030cb7bd624e250ce32002455927"}
- experimental_model
- Observational cohort and separate uncontrolled pilot
- exposure
- 162-person cohort; ten-person pilot, lysine chloride 115 mmol/day for three days
- limitations
- Association does not establish causality; the small pilot did not prove clinical benefit or survival improvement.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Human heart failure patients
- plain_language
- The study tested a way to supply chloride without sodium; benefit remains unresolved.
- primary_references
- [chloride-p27507113] Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights. (2016). https://pubmed.ncbi.nlm.nih.gov/27507113/ DOI: 10.1161/circheartfailure.116.003180
- tissue_or_cell_type
- Blood and renal diuretic response
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 952–963
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Observational cohort and separate uncontrolled pilot · source_derived_draft · unverified_draft
### chloride-lysine-chloride The pilot reported a mean serum chloride rise of 2.2 mmol/L after sodium-free lysine chloride supplementation. Condition category: normal nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: The study tested a way to supply chloride without sodium; benefit remains unresolved. organism: Human heart failure patients tissue_or_cell_type: Blood and renal diuretic response experimental_model: Observational cohort and separate uncontrolled pilot limitations: Association does not establish causality; the small pilot did not prove clinical benefit or survival improvement. exposure: 162-person cohort; ten-person pilot, lysine chloride 115 mmol/day for three days evidence_span: {"source_cache": "artifacts/chloride-research/27507113.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "978879bf8054ce7c99ef939133966e618cc8030cb7bd624e250ce32002455927", "start_char": 0, "end_char": 2050, "text_sha256": "978879bf8054ce7c99ef939133966e618cc8030cb7bd624e250ce32002455927"} [chloride-p27507113] Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights. (2016). https://pubmed.ncbi.nlm.nih.gov/27507113/ DOI: 10.1161/circheartfailure.116.003180
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.