Fractional absorption of administered lycopene: molecular mechanisms & dependencies

How nutrients influence it

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Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

Modeled bioavailability did not differ between cis lycopene, 24.5% ± 6%, and all-trans lycopene, 23.2% ± 8%.
Study-specified cis-lycopene isomer pool → Fractional absorption of administered lycopene source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/lycopene-research/26561629.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682", "start_char": 0, "end_char": 2207, "text_sha256": "fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682"}
experimental_model
Stable-isotope tracer and seven-compartment kinetic modeling
exposure
10.2 mg carbon-13 lycopene, 82% all-trans and 18% cis
limitations
Small study; model-dependent pool estimates; formulation differs from food-matrix comparisons.
nutrient_topic
Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
organism
Human, eight healthy adults
plain_language
Cis forms were not universally better absorbed under these conditions.
primary_references
[lycopene-p26561629] Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. (2015). https://pubmed.ncbi.nlm.nih.gov/26561629/ DOI: 10.3945/ajcn.114.103143
tissue_or_cell_type
Plasma over 28 days and modeled tissue pools
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 208–219
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stable-isotope tracer and seven-compartment kinetic modeling · source_derived_draft · unverified_draft
### lycopene-isomer-absorption-null Modeled bioavailability did not differ between cis lycopene, 24.5% ± 6%, and all-trans lycopene, 23.2% ± 8%. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Cis forms were not universally better absorbed under these conditions. organism: Human, eight healthy adults tissue_or_cell_type: Plasma over 28 days and modeled tissue pools experimental_model: Stable-isotope tracer and seven-compartment kinetic modeling limitations: Small study; model-dependent pool estimates; formulation differs from food-matrix comparisons. exposure: 10.2 mg carbon-13 lycopene, 82% all-trans and 18% cis evidence_span: {"source_cache": "artifacts/lycopene-research/26561629.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682", "start_char": 0, "end_char": 2207, "text_sha256": "fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682"} [lycopene-p26561629] Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. (2015). https://pubmed.ncbi.nlm.nih.gov/26561629/ DOI: 10.3945/ajcn.114.103143
Complete structured claim and evidence
Mean fractional lycopene absorption was 23% ± 6% in the human carbon-13 tracer experiment.
Lycopene → Fractional absorption of administered lycopene source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/lycopene-research/26561629.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682", "start_char": 0, "end_char": 2207, "text_sha256": "fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682"}
experimental_model
Stable-isotope tracer and seven-compartment kinetic modeling
exposure
10.2 mg carbon-13 lycopene, 82% all-trans and 18% cis
limitations
Small study; model-dependent pool estimates; formulation differs from food-matrix comparisons.
nutrient_topic
Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
organism
Human, eight healthy adults
plain_language
Only part of an oral dose reached the body in this study.
primary_references
[lycopene-p26561629] Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. (2015). https://pubmed.ncbi.nlm.nih.gov/26561629/ DOI: 10.3945/ajcn.114.103143
tissue_or_cell_type
Plasma over 28 days and modeled tissue pools
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 195–206
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stable-isotope tracer and seven-compartment kinetic modeling · source_derived_draft · unverified_draft
### lycopene-tracer-absorption Mean fractional lycopene absorption was 23% ± 6% in the human carbon-13 tracer experiment. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Only part of an oral dose reached the body in this study. organism: Human, eight healthy adults tissue_or_cell_type: Plasma over 28 days and modeled tissue pools experimental_model: Stable-isotope tracer and seven-compartment kinetic modeling limitations: Small study; model-dependent pool estimates; formulation differs from food-matrix comparisons. exposure: 10.2 mg carbon-13 lycopene, 82% all-trans and 18% cis evidence_span: {"source_cache": "artifacts/lycopene-research/26561629.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682", "start_char": 0, "end_char": 2207, "text_sha256": "fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682"} [lycopene-p26561629] Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. (2015). https://pubmed.ncbi.nlm.nih.gov/26561629/ DOI: 10.3945/ajcn.114.103143
Complete structured claim and evidence

The events it takes part in

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Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

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Open hypotheses

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This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Fractional absorption of administered lycopene