Component

Lactoperoxidase catalytic activity

Study-specific endpoint; inspect claim context for model and measurement.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Inhibiting LPO activity increased lung lesions, RSV mRNA and antigen in the lamb experiment.

    Lactoperoxidase catalytic activity → RSV-associated lung lesions in lambs source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Newborn and three-week-old lamb RSV experiments; oral KI given by intragastric gavage.
    exposure_category
    Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.
    limitations
    Animal disease model; no human antiviral efficacy established. LPO inhibition supports pathway involvement, not an exclusively LPO mechanism.
    nutrient_topic
    Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions. · Potassium iodide
    plain_language
    Blocking the enzyme weakened protection.
    primary_references
    Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24053146/ · DOI 10.1165/rcmb.2012-0529oc

    Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18) · lines 120–126

    AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text. · supports · Newborn and three-week-old lamb RSV experiments; oral KI given by intragastric gavage. · source_derived_draft · unverified_draft

    ## ki-lamb-lpo-block Blocking the enzyme weakened protection. Inhibiting LPO activity increased lung lesions, RSV mRNA and antigen in the lamb experiment. Model: Newborn and three-week-old lamb RSV experiments; oral KI given by intragastric gavage. Limitations: Animal disease model; no human antiviral efficacy established. LPO inhibition supports pathway involvement, not an exclusively LPO mechanism. Evidence location: Primary abstract Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24053146/ · DOI 10.1165/rcmb.2012-0529oc
    Complete structured claim and evidence

What acts on it

  1. Hypoiodite occupied the distal heme cavity; ABTS activity experiments supported product inhibition.

    Hypoiodite ion (OI−) → Lactoperoxidase catalytic activity source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Purified LPO crystallography and activity assays; ammonium iodide supplied the anion, not KI.
    exposure_category
    Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.
    limitations
    Structural/biochemical model; enzyme species not assigned from abstract. Cofactor chemistry does not establish dietary iron responsiveness.
    nutrient_topic
    Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions. · Potassium iodide
    plain_language
    The enzyme product can limit further enzyme activity.
    primary_references
    Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase. · 2022 · https://pubmed.ncbi.nlm.nih.gov/34761444/ · DOI 10.1002/pro.4230

    Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18) · lines 240–246

    AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text. · supports · Purified LPO crystallography and activity assays; ammonium iodide supplied the anion, not KI. · source_derived_draft · unverified_draft

    ## ki-lpo-feedback The enzyme product can limit further enzyme activity. Hypoiodite occupied the distal heme cavity; ABTS activity experiments supported product inhibition. Model: Purified LPO crystallography and activity assays; ammonium iodide supplied the anion, not KI. Limitations: Structural/biochemical model; enzyme species not assigned from abstract. Cofactor chemistry does not establish dietary iron responsiveness. Evidence location: Primary abstract Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase. · 2022 · https://pubmed.ncbi.nlm.nih.gov/34761444/ · DOI 10.1002/pro.4230
    Complete structured claim and evidence

  2. Preincubating LPO with ammonium iodide decreased measured catalytic activity and stabilized a peroxide–iodide ternary complex.

    Iodide ion → Lactoperoxidase catalytic activity source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Purified LPO crystallography and activity assays; ammonium iodide supplied the anion, not KI.
    exposure_category
    Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.
    limitations
    Structural/biochemical model; enzyme species not assigned from abstract. Cofactor chemistry does not establish dietary iron responsiveness.
    nutrient_topic
    Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions. · Potassium iodide
    plain_language
    Iodide can inhibit the enzyme under a different order of exposure.
    primary_references
    Structure of a ternary complex of lactoperoxidase with iodide and hydrogen peroxide at 1.77 Å resolution. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33882424/ · DOI 10.1016/j.jinorgbio.2021.111461

    Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18) · lines 224–230

    AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text. · supports · Purified LPO crystallography and activity assays; ammonium iodide supplied the anion, not KI. · source_derived_draft · unverified_draft

    ## ki-lpo-substrate-block Iodide can inhibit the enzyme under a different order of exposure. Preincubating LPO with ammonium iodide decreased measured catalytic activity and stabilized a peroxide–iodide ternary complex. Model: Purified LPO crystallography and activity assays; ammonium iodide supplied the anion, not KI. Limitations: Structural/biochemical model; enzyme species not assigned from abstract. Cofactor chemistry does not establish dietary iron responsiveness. Evidence location: Primary abstract Structure of a ternary complex of lactoperoxidase with iodide and hydrogen peroxide at 1.77 Å resolution. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33882424/ · DOI 10.1016/j.jinorgbio.2021.111461
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards