{"id":"5217a50c-a510-5688-aee9-be0c4a27b75b","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-lamb-lpo-block","predicate":"modulates","statement":"Inhibiting LPO activity increased lung lesions, RSV mRNA and antigen in the lamb experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"33bbe390-ddc1-55fc-b496-43646d53e54e","mechanism_event_label":"Blocking the enzyme weakened protection.","subject":{"id":"ae57b6a5-04e5-512c-bdad-87430178a058","slug":"lpo-catalytic-activity","display_name":"Lactoperoxidase catalytic activity","entity_type_key":"cellular_process"},"object":{"id":"2a93ca21-4dd8-5b23-b65d-b1ab3aa892c6","slug":"lamb-rsv-lung-lesions","display_name":"RSV-associated lung lesions in lambs","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"33bbe390-ddc1-55fc-b496-43646d53e54e","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-lamb-lpo-block-event","event_type":"observed_relationship","label":"Blocking the enzyme weakened protection.","description":"Inhibiting LPO activity increased lung lesions, RSV mRNA and antigen in the lamb experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ae57b6a5-04e5-512c-bdad-87430178a058","slug":"lpo-catalytic-activity","display_name":"Lactoperoxidase catalytic activity","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a93ca21-4dd8-5b23-b65d-b1ab3aa892c6","slug":"lamb-rsv-lung-lesions","display_name":"RSV-associated lung lesions in lambs","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3d671567-4fb6-5b5f-a328-156987d5b396","slug":"lactoperoxidase-family","display_name":"Lactoperoxidase enzyme family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Newborn and three-week-old lamb RSV experiments; oral KI given by intragastric gavage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal disease model; no human antiviral efficacy established. LPO inhibition supports pathway involvement, not an exclusively LPO mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Blocking the enzyme weakened protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24053146/ · DOI 10.1165/rcmb.2012-0529oc","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7d8ae625-f4de-5c24-901f-db499f7a0445","evidence_kind":"source_excerpt","locator":"Lines 120-126","start_line":120,"end_line":126,"excerpt":"## ki-lamb-lpo-block\nBlocking the enzyme weakened protection.\nInhibiting LPO activity increased lung lesions, RSV mRNA and antigen in the lamb experiment.\nModel: Newborn and three-week-old lamb RSV experiments; oral KI given by intragastric gavage.\nLimitations: Animal disease model; no human antiviral efficacy established. LPO inhibition supports pathway involvement, not an exclusively LPO mechanism.\nEvidence location: Primary abstract\nIncreased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24053146/ · DOI 10.1165/rcmb.2012-0529oc","model_system":"Newborn and three-week-old lamb RSV experiments; oral KI given by intragastric gavage.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. 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