Component

Intestinal epithelial lutein uptake

Intestinal epithelial lutein uptake. Species, exposure and limitations are retained in each linked claim.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Co-incubated beta-carotene reduced lutein absorption by approximately 20% in this cell model.

    All-trans-beta-carotene → Intestinal epithelial lutein uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lutein-research/15554873.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0", "start_char": 0, "end_char": 2014, "text_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0"}
    experimental_model
    Mixed-micelle transport across Caco-2 TC-7 monolayers
    exposure
    Micellar lutein 1.5–15 micromolar; antibodies and BLT1
    limitations
    Partial inhibition supports a contribution, not an exclusive route; cell experiments do not set clinical supplement spacing.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Human intestinal cell model
    plain_language
    Another carotenoid competed under these conditions.
    primary_references
    [lutein-p15554873] Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI). (2005). https://pubmed.ncbi.nlm.nih.gov/15554873/ DOI: 10.1042/bj20040554
    tissue_or_cell_type
    Apical intestinal epithelial transport

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 489–500

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mixed-micelle transport across Caco-2 TC-7 monolayers · source_derived_draft · unverified_draft

    ### lutein-beta-competition Co-incubated beta-carotene reduced lutein absorption by approximately 20% in this cell model. Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: Another carotenoid competed under these conditions. organism: Human intestinal cell model tissue_or_cell_type: Apical intestinal epithelial transport experimental_model: Mixed-micelle transport across Caco-2 TC-7 monolayers limitations: Partial inhibition supports a contribution, not an exclusive route; cell experiments do not set clinical supplement spacing. exposure: Micellar lutein 1.5–15 micromolar; antibodies and BLT1 evidence_span: {"source_cache": "artifacts/lutein-research/15554873.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0", "start_char": 0, "end_char": 2014, "text_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0"} [lutein-p15554873] Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI). (2005). https://pubmed.ncbi.nlm.nih.gov/15554873/ DOI: 10.1042/bj20040554
    Complete structured claim and evidence

  2. Ezetimibe reduced lutein accumulation by up to 40% in Caco-2 monolayers.

    Ezetimibe → Intestinal epithelial lutein uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lutein-research/22579005.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1dd51af5fd10e865810b3fa2fdab5ed4f6613212a3cd418a009554ae601c076b", "start_char": 0, "end_char": 1895, "text_sha256": "1dd51af5fd10e865810b3fa2fdab5ed4f6613212a3cd418a009554ae601c076b"}
    experimental_model
    Transporter-inhibitor uptake/permeability experiment
    exposure
    Ezetimibe, BLT1 and ATP-depletion reagents
    limitations
    Pharmacological evidence supports involvement, not an exclusive transporter or proven human clinical interaction.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Human Caco-2 cells
    plain_language
    The medicine reduced cellular uptake in this experiment.
    primary_references
    [lutein-p22579005] Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein. (2012). https://pubmed.ncbi.nlm.nih.gov/22579005/ DOI: 10.18433/j38k56
    tissue_or_cell_type
    Intestinal epithelial model

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 528–539

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter-inhibitor uptake/permeability experiment · source_derived_draft · unverified_draft

    ### lutein-ezetimibe-intestine Ezetimibe reduced lutein accumulation by up to 40% in Caco-2 monolayers. Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: The medicine reduced cellular uptake in this experiment. organism: Human Caco-2 cells tissue_or_cell_type: Intestinal epithelial model experimental_model: Transporter-inhibitor uptake/permeability experiment limitations: Pharmacological evidence supports involvement, not an exclusive transporter or proven human clinical interaction. exposure: Ezetimibe, BLT1 and ATP-depletion reagents evidence_span: {"source_cache": "artifacts/lutein-research/22579005.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1dd51af5fd10e865810b3fa2fdab5ed4f6613212a3cd418a009554ae601c076b", "start_char": 0, "end_char": 1895, "text_sha256": "1dd51af5fd10e865810b3fa2fdab5ed4f6613212a3cd418a009554ae601c076b"} [lutein-p22579005] Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein. (2012). https://pubmed.ncbi.nlm.nih.gov/22579005/ DOI: 10.18433/j38k56
    Complete structured claim and evidence

  3. Lycopene did not significantly reduce lutein uptake in the same mixed-micelle assay.

    Lycopene → Intestinal epithelial lutein uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lutein-research/15554873.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0", "start_char": 0, "end_char": 2014, "text_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0"}
    experimental_model
    Mixed-micelle transport across Caco-2 TC-7 monolayers
    exposure
    Micellar lutein 1.5–15 micromolar; antibodies and BLT1
    limitations
    Partial inhibition supports a contribution, not an exclusive route; cell experiments do not set clinical supplement spacing.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Human intestinal cell model
    plain_language
    Shared transport does not mean every pair competes equally.
    primary_references
    [lutein-p15554873] Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI). (2005). https://pubmed.ncbi.nlm.nih.gov/15554873/ DOI: 10.1042/bj20040554
    tissue_or_cell_type
    Apical intestinal epithelial transport

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 502–513

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mixed-micelle transport across Caco-2 TC-7 monolayers · source_derived_draft · unverified_draft

    ### lutein-lycopene-null Lycopene did not significantly reduce lutein uptake in the same mixed-micelle assay. Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: Shared transport does not mean every pair competes equally. organism: Human intestinal cell model tissue_or_cell_type: Apical intestinal epithelial transport experimental_model: Mixed-micelle transport across Caco-2 TC-7 monolayers limitations: Partial inhibition supports a contribution, not an exclusive route; cell experiments do not set clinical supplement spacing. exposure: Micellar lutein 1.5–15 micromolar; antibodies and BLT1 evidence_span: {"source_cache": "artifacts/lutein-research/15554873.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0", "start_char": 0, "end_char": 2014, "text_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0"} [lutein-p15554873] Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI). (2005). https://pubmed.ncbi.nlm.nih.gov/15554873/ DOI: 10.1042/bj20040554
    Complete structured claim and evidence

  4. Ezetimibe-sensitive lutein uptake supported a contribution from NPC1L1 in Caco-2 cells.

    Human Niemann-Pick C1-like protein 1 / NPC1L1 → Intestinal epithelial lutein uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lutein-research/22579005.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1dd51af5fd10e865810b3fa2fdab5ed4f6613212a3cd418a009554ae601c076b", "start_char": 0, "end_char": 1895, "text_sha256": "1dd51af5fd10e865810b3fa2fdab5ed4f6613212a3cd418a009554ae601c076b"}
    experimental_model
    Transporter-inhibitor uptake/permeability experiment
    exposure
    Ezetimibe, BLT1 and ATP-depletion reagents
    limitations
    Pharmacological evidence supports involvement, not an exclusive transporter or proven human clinical interaction.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Human Caco-2 cells
    plain_language
    A cholesterol-uptake pathway also contributed to lutein entry.
    primary_references
    [lutein-p22579005] Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein. (2012). https://pubmed.ncbi.nlm.nih.gov/22579005/ DOI: 10.18433/j38k56
    tissue_or_cell_type
    Intestinal epithelial model

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 515–526

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter-inhibitor uptake/permeability experiment · source_derived_draft · unverified_draft

    ### lutein-npc1l1-intestine Ezetimibe-sensitive lutein uptake supported a contribution from NPC1L1 in Caco-2 cells. Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: A cholesterol-uptake pathway also contributed to lutein entry. organism: Human Caco-2 cells tissue_or_cell_type: Intestinal epithelial model experimental_model: Transporter-inhibitor uptake/permeability experiment limitations: Pharmacological evidence supports involvement, not an exclusive transporter or proven human clinical interaction. exposure: Ezetimibe, BLT1 and ATP-depletion reagents evidence_span: {"source_cache": "artifacts/lutein-research/22579005.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1dd51af5fd10e865810b3fa2fdab5ed4f6613212a3cd418a009554ae601c076b", "start_char": 0, "end_char": 1895, "text_sha256": "1dd51af5fd10e865810b3fa2fdab5ed4f6613212a3cd418a009554ae601c076b"} [lutein-p22579005] Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein. (2012). https://pubmed.ncbi.nlm.nih.gov/22579005/ DOI: 10.18433/j38k56
    Complete structured claim and evidence

  5. SR-BI antibody and BLT1 reduced lutein transport by approximately 30% and 57%, respectively.

    Scavenger receptor class B type 1 / SCARB1 → Intestinal epithelial lutein uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lutein-research/15554873.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0", "start_char": 0, "end_char": 2014, "text_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0"}
    experimental_model
    Mixed-micelle transport across Caco-2 TC-7 monolayers
    exposure
    Micellar lutein 1.5–15 micromolar; antibodies and BLT1
    limitations
    Partial inhibition supports a contribution, not an exclusive route; cell experiments do not set clinical supplement spacing.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Human intestinal cell model
    plain_language
    Part of intestinal uptake used the SR-BI pathway.
    primary_references
    [lutein-p15554873] Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI). (2005). https://pubmed.ncbi.nlm.nih.gov/15554873/ DOI: 10.1042/bj20040554
    tissue_or_cell_type
    Apical intestinal epithelial transport

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 476–487

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mixed-micelle transport across Caco-2 TC-7 monolayers · source_derived_draft · unverified_draft

    ### lutein-srbi-intestine SR-BI antibody and BLT1 reduced lutein transport by approximately 30% and 57%, respectively. Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: Part of intestinal uptake used the SR-BI pathway. organism: Human intestinal cell model tissue_or_cell_type: Apical intestinal epithelial transport experimental_model: Mixed-micelle transport across Caco-2 TC-7 monolayers limitations: Partial inhibition supports a contribution, not an exclusive route; cell experiments do not set clinical supplement spacing. exposure: Micellar lutein 1.5–15 micromolar; antibodies and BLT1 evidence_span: {"source_cache": "artifacts/lutein-research/15554873.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0", "start_char": 0, "end_char": 2014, "text_sha256": "3dfbef37e3c73db4732f66083063e548a1654cb759ff46392c981c50f338d8a0"} [lutein-p15554873] Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI). (2005). https://pubmed.ncbi.nlm.nih.gov/15554873/ DOI: 10.1042/bj20040554
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards