Component
Insomnia Severity Index score
Insomnia Severity Index score. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Theanine did not significantly outperform placebo on total insomnia severity (p=0.35).
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/theanine-research/30580081.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837", "start_char": 0, "end_char": 1664, "text_sha256": "00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837"}
- experimental_model
- Double-blind placebo-controlled adjunctive trial
- exposure
- 450-900 mg/day theanine for eight weeks
- limitations
- Adjunctive setting with stable medication. Overall negative anxiety and insomnia endpoints; a favorable sleep-satisfaction item is narrower.
- nutrient_topic
- L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
- organism
- 46 people with generalized anxiety disorder on stable antidepressants
- plain_language
- The overall sleep scale was negative despite a favorable individual item.
- primary_references
- [theanine-p30580081] L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/30580081/ DOI: 10.1016/j.jpsychires.2018.12.014
- tissue_or_cell_type
- Anxiety and insomnia scales
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 1121–1132
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled adjunctive trial · source_derived_draft · unverified_draft
### theanine-gad-insomnia-null Theanine did not significantly outperform placebo on total insomnia severity (p=0.35). Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The overall sleep scale was negative despite a favorable individual item. organism: 46 people with generalized anxiety disorder on stable antidepressants tissue_or_cell_type: Anxiety and insomnia scales experimental_model: Double-blind placebo-controlled adjunctive trial limitations: Adjunctive setting with stable medication. Overall negative anxiety and insomnia endpoints; a favorable sleep-satisfaction item is narrower. exposure: 450-900 mg/day theanine for eight weeks evidence_span: {"source_cache": "artifacts/theanine-research/30580081.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837", "start_char": 0, "end_char": 1664, "text_sha256": "00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837"} [theanine-p30580081] L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/30580081/ DOI: 10.1016/j.jpsychires.2018.12.014
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.