{"id":"c2230170-3488-54c4-b8fe-03f2e35265bf","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-gad-insomnia-null","predicate":"did_not_outperform_placebo_for","statement":"Theanine did not significantly outperform placebo on total insomnia severity (p=0.35).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8a4f5995-c4d2-5f4f-8ae2-4fe32cbeef3b","mechanism_event_label":"The overall sleep scale was negative despite a favorable individual item.","subject":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"object":{"id":"8c0fc373-ab50-5682-a65d-324374e662e6","slug":"insomnia-severity-score","display_name":"Insomnia Severity Index score","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8a4f5995-c4d2-5f4f-8ae2-4fe32cbeef3b","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-gad-insomnia-null-event","event_type":"observed_intervention","label":"The overall sleep scale was negative despite a favorable individual item.","description":"Theanine did not significantly outperform placebo on total insomnia severity (p=0.35).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8c0fc373-ab50-5682-a65d-324374e662e6","slug":"insomnia-severity-score","display_name":"Insomnia Severity Index score","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/30580081.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837\", \"start_char\": 0, \"end_char\": 1664, \"text_sha256\": \"00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind placebo-controlled adjunctive trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"450-900 mg/day theanine for eight weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Adjunctive setting with stable medication. 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Overall negative anxiety and insomnia endpoints; a favorable sleep-satisfaction item is narrower.\nexposure: 450-900 mg/day theanine for eight weeks\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/30580081.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837\", \"start_char\": 0, \"end_char\": 1664, \"text_sha256\": \"00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837\"}\n[theanine-p30580081] L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. 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