Component

Inositol 1,3,4,5,6-pentakisphosphate

Inositol 1,3,4,5,6-pentakisphosphate. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Recombinant human IPMK phosphorylated IP3 at positions 3 and 6, reaching inositol 1,3,4,5,6-pentakisphosphate.

    IPMK (human inositol phosphate multikinase) → Inositol 1,3,4,5,6-pentakisphosphate source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/12027805.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d015b4f1e5198aceb869411c91fd2ab00da093fb573c1b195305fe8adfe66b26", "start_char": 0, "end_char": 1282, "text_sha256": "d015b4f1e5198aceb869411c91fd2ab00da093fb573c1b195305fe8adfe66b26"}
    experimental_model
    Human cDNA cloning and recombinant kinase characterization
    exposure
    IP3 phosphorylation and product analysis
    limitations
    Enzyme activity and expression-system localization do not establish dietary effects or a single obligatory route for all cells.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human protein expressed in bacteria and mammalian cells
    plain_language
    The multikinase supplies a route from IP3 toward the five-phosphate precursor of InsP6.
    primary_references
    [ino-p12027805] The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. (2002). https://pubmed.ncbi.nlm.nih.gov/12027805/ DOI: 10.1042/bj20020327
    tissue_or_cell_type
    Recombinant enzyme and tagged-protein localization

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 704–715

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human cDNA cloning and recombinant kinase characterization · source_derived_draft · unverified_draft

    ### ino-ipmk-ip5 Recombinant human IPMK phosphorylated IP3 at positions 3 and 6, reaching inositol 1,3,4,5,6-pentakisphosphate. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The multikinase supplies a route from IP3 toward the five-phosphate precursor of InsP6. organism: Human protein expressed in bacteria and mammalian cells tissue_or_cell_type: Recombinant enzyme and tagged-protein localization experimental_model: Human cDNA cloning and recombinant kinase characterization limitations: Enzyme activity and expression-system localization do not establish dietary effects or a single obligatory route for all cells. exposure: IP3 phosphorylation and product analysis evidence_span: {"source_cache": "artifacts/inositol-research/12027805.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d015b4f1e5198aceb869411c91fd2ab00da093fb573c1b195305fe8adfe66b26", "start_char": 0, "end_char": 1282, "text_sha256": "d015b4f1e5198aceb869411c91fd2ab00da093fb573c1b195305fe8adfe66b26"} [ino-p12027805] The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. (2002). https://pubmed.ncbi.nlm.nih.gov/12027805/ DOI: 10.1042/bj20020327
    Complete structured claim and evidence

  2. Human IPPK used ATP to phosphorylate inositol 1,3,4,5,6-pentakisphosphate at position 2, producing InsP6.

    IPPK (human inositol-pentakisphosphate 2-kinase) → Inositol 1,3,4,5,6-pentakisphosphate source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/12084730.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7e44dbc7039048a53bffd92fd69dfa1f35f1dc762389c8d810f913ea70e10c80", "start_char": 0, "end_char": 1407, "text_sha256": "7e44dbc7039048a53bffd92fd69dfa1f35f1dc762389c8d810f913ea70e10c80"}
    experimental_model
    Recombinant kinase and yeast complementation
    exposure
    Inositol pentakisphosphate and ATP assays
    limitations
    Human enzyme activity; yeast rescue is not a clinical supplementation trial.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human IPPK expressed in Sf21 cells
    plain_language
    The cell can make the six-phosphate inositol molecule inside itself.
    primary_references
    [ino-p12084730] The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase. (2002). https://pubmed.ncbi.nlm.nih.gov/12084730/ DOI: 10.1074/jbc.m205682200
    tissue_or_cell_type
    Purified kinase

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 743–754

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant kinase and yeast complementation · source_derived_draft · unverified_draft

    ### ino-ippk-ip6 Human IPPK used ATP to phosphorylate inositol 1,3,4,5,6-pentakisphosphate at position 2, producing InsP6. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cell can make the six-phosphate inositol molecule inside itself. organism: Human IPPK expressed in Sf21 cells tissue_or_cell_type: Purified kinase experimental_model: Recombinant kinase and yeast complementation limitations: Human enzyme activity; yeast rescue is not a clinical supplementation trial. exposure: Inositol pentakisphosphate and ATP assays evidence_span: {"source_cache": "artifacts/inositol-research/12084730.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7e44dbc7039048a53bffd92fd69dfa1f35f1dc762389c8d810f913ea70e10c80", "start_char": 0, "end_char": 1407, "text_sha256": "7e44dbc7039048a53bffd92fd69dfa1f35f1dc762389c8d810f913ea70e10c80"} [ino-p12084730] The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase. (2002). https://pubmed.ncbi.nlm.nih.gov/12084730/ DOI: 10.1074/jbc.m205682200
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards