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(2002). https://pubmed.ncbi.nlm.nih.gov/12027805/ DOI: 10.1042/bj20020327","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Recombinant enzyme and tagged-protein localization","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d5bcecf1-a6e3-5999-b32c-1eed1c0acbcf","evidence_kind":"source_excerpt","locator":"Lines 704-715","start_line":704,"end_line":715,"excerpt":"### ino-ipmk-ip5\nRecombinant human IPMK phosphorylated IP3 at positions 3 and 6, reaching inositol 1,3,4,5,6-pentakisphosphate.\nCondition category: normal\nnutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The multikinase supplies a route from IP3 toward the five-phosphate precursor of InsP6.\norganism: Human protein expressed in bacteria and mammalian cells\ntissue_or_cell_type: Recombinant enzyme and tagged-protein localization\nexperimental_model: Human cDNA cloning and recombinant kinase characterization\nlimitations: Enzyme activity and expression-system localization do not establish dietary effects or a single obligatory route for all cells.\nexposure: IP3 phosphorylation and product analysis\nevidence_span: {\"source_cache\": \"artifacts/inositol-research/12027805.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d015b4f1e5198aceb869411c91fd2ab00da093fb573c1b195305fe8adfe66b26\", \"start_char\": 0, \"end_char\": 1282, \"text_sha256\": \"d015b4f1e5198aceb869411c91fd2ab00da093fb573c1b195305fe8adfe66b26\"}\n[ino-p12027805] The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. 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