Component
Importin alpha/beta nuclear import complex
Heterodimeric carrier for classical nuclear localisation signal cargo.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Ivermectin inhibited importin alpha/beta-mediated nuclear import broadly, with no effect on a range of other nuclear import pathways including import mediated by importin beta1 alone.
Experimental context and source evidence
- duration
- Acute
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- Nuclear transport assays following a high-throughput screen
- exposure
- Ivermectin
- limitations
- Specificity here is specificity among import pathways; the concentration required is not stated in the abstract.
- organism
- Nuclear transport assays following a high-throughput screen
- plain_language
- Ivermectin inhibited importin alpha/beta-mediated nuclear import broadly, with no effect on a range of other nuclear import pathways including import mediated by importin beta1 alone.
- primary_references
- Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. (2012). https://pubmed.ncbi.nlm.nih.gov/22417684/ DOI: 10.1042/BJ20120150
- route
- In vitro
- tissue
- Protein movement between cytoplasm and nucleus
Ivermectin: mechanism of action across parasite, host barrier and mammalian targets (2026-09-22) · lines 145–154
Original AI-assisted curation of sixteen primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Study-specific citations, concentrations, negative findings and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## ivermectin-importin-nuclear-import Ivermectin inhibited importin alpha/beta-mediated nuclear import broadly, with no effect on a range of other nuclear import pathways including import mediated by importin beta1 alone. Model/species: Nuclear transport assays following a high-throughput screen Tissue/system: Protein movement between cytoplasm and nucleus Exposure: Ivermectin Route: In vitro Duration: Acute Limits: Specificity here is specificity among import pathways; the concentration required is not stated in the abstract. Primary reference: Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. (2012). https://pubmed.ncbi.nlm.nih.gov/22417684/ DOI: 10.1042/BJ20120150 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
Where it participates (unsigned role)
Ivermectin inhibited replication of HIV-1 and dengue virus, both of which depend on importin alpha/beta nuclear import of HIV-1 integrase and dengue NS5 polymerase respectively.
Experimental context and source evidence
- duration
- Not stated here
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- HIV-1 and dengue virus replication assays
- exposure
- Ivermectin
- limitations
- Antiviral activity in culture is attributed to the import mechanism by inference from the known import dependence of these viral proteins.
- organism
- HIV-1 and dengue virus replication assays
- plain_language
- Ivermectin inhibited replication of HIV-1 and dengue virus, both of which depend on importin alpha/beta nuclear import of HIV-1 integrase and dengue NS5 polymerase respectively.
- primary_references
- Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. (2012). https://pubmed.ncbi.nlm.nih.gov/22417684/ DOI: 10.1042/BJ20120150
- route
- In vitro
- tissue
- Viral protein nuclear import
Ivermectin: mechanism of action across parasite, host barrier and mammalian targets (2026-09-22) · lines 156–165
Original AI-assisted curation of sixteen primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Study-specific citations, concentrations, negative findings and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## ivermectin-hiv-dengue-replication Ivermectin inhibited replication of HIV-1 and dengue virus, both of which depend on importin alpha/beta nuclear import of HIV-1 integrase and dengue NS5 polymerase respectively. Model/species: HIV-1 and dengue virus replication assays Tissue/system: Viral protein nuclear import Exposure: Ivermectin Route: In vitro Duration: Not stated here Limits: Antiviral activity in culture is attributed to the import mechanism by inference from the known import dependence of these viral proteins. Primary reference: Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. (2012). https://pubmed.ncbi.nlm.nih.gov/22417684/ DOI: 10.1042/BJ20120150 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.