{"id":"d9df51aa-2f74-531c-af19-20325630f9b3","stable_key":"e0801c92-7fd3-5cb2-82b7-dd82f010f3ed:ivermectin-importin-nuclear-import","predicate":"inhibits","statement":"Ivermectin inhibited importin alpha/beta-mediated nuclear import broadly, with no effect on a range of other nuclear import pathways including import mediated by importin beta1 alone.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"656f774f-2491-56dd-879f-80ef72bc1fea","mechanism_event_label":"Ivermectin inhibited importin alpha/beta-mediated nuclear import broadly, with no effect on a range of other nuclear import pathways including import mediated by importin beta1 alone.","subject":{"id":"416b9886-c6a5-5526-a8bf-b571a8d418bf","slug":"ivermectin","display_name":"Ivermectin","entity_type_key":"drug"},"object":{"id":"b65fe2e8-46e5-58a8-9198-a4c4c713c08e","slug":"importin-alpha-beta","display_name":"Importin alpha/beta nuclear import complex","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"656f774f-2491-56dd-879f-80ef72bc1fea","stable_key":"e0801c92-7fd3-5cb2-82b7-dd82f010f3ed:ivermectin-importin-nuclear-import-event","event_type":"observed_relationship","label":"Ivermectin inhibited importin alpha/beta-mediated nuclear import broadly, with no effect on a range of other nuclear import pathways including import mediated by importin beta1 alone.","description":"Ivermectin inhibited importin alpha/beta-mediated nuclear import broadly, with no effect on a range of other nuclear import pathways including import mediated by importin beta1 alone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"416b9886-c6a5-5526-a8bf-b571a8d418bf","slug":"ivermectin","display_name":"Ivermectin","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b65fe2e8-46e5-58a8-9198-a4c4c713c08e","slug":"importin-alpha-beta","display_name":"Importin alpha/beta nuclear import complex","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Acute","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Nuclear transport assays following a high-throughput screen","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ivermectin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Specificity here is specificity among import pathways; the concentration required is not stated in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Nuclear transport assays following a high-throughput screen","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Ivermectin inhibited importin alpha/beta-mediated nuclear import broadly, with no effect on a range of other nuclear import pathways including import mediated by importin beta1 alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. (2012). https://pubmed.ncbi.nlm.nih.gov/22417684/ DOI: 10.1042/BJ20120150","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Protein movement between cytoplasm and nucleus","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fc3ffc87-87d5-5d41-b7d2-8563b8345f40","evidence_kind":"source_excerpt","locator":"Lines 145-154","start_line":145,"end_line":154,"excerpt":"## ivermectin-importin-nuclear-import\nIvermectin inhibited importin alpha/beta-mediated nuclear import broadly, with no effect on a range of other nuclear import pathways including import mediated by importin beta1 alone.\nModel/species: Nuclear transport assays following a high-throughput screen\nTissue/system: Protein movement between cytoplasm and nucleus\nExposure: Ivermectin\nRoute: In vitro\nDuration: Acute\nLimits: Specificity here is specificity among import pathways; the concentration required is not stated in the abstract.\nPrimary reference: Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. (2012). https://pubmed.ncbi.nlm.nih.gov/22417684/ DOI: 10.1042/BJ20120150\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"20818ddd-7b37-5226-a24b-7de007e80eb2","stable_key":"import-e0801c92-7fd3-5cb2-82b7-dd82f010f3ed","title":"Ivermectin: mechanism of action across parasite, host barrier and mammalian targets (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of sixteen primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Study-specific citations, concentrations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"c7e1e0201cbd222f0c52b7981f078936ed39b617d747821ed6daa584c2b964a7","revision_id":"56746c3e-cdec-5b8f-a191-425de1a0a7ce","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}