{"id":"f2b80c3a-54a2-5ca0-b8d4-e1c09cc19860","stable_key":"e0801c92-7fd3-5cb2-82b7-dd82f010f3ed:ivermectin-hiv-dengue-replication","predicate":"reduces","statement":"Ivermectin inhibited replication of HIV-1 and dengue virus, both of which depend on importin alpha/beta nuclear import of HIV-1 integrase and dengue NS5 polymerase respectively.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"323ae611-86cf-5006-a22c-1926297babae","mechanism_event_label":"Ivermectin inhibited replication of HIV-1 and dengue virus, both of which depend on importin alpha/beta nuclear import of HIV-1 integrase and dengue NS5 polymerase respectively.","subject":{"id":"416b9886-c6a5-5526-a8bf-b571a8d418bf","slug":"ivermectin","display_name":"Ivermectin","entity_type_key":"drug"},"object":{"id":"ca1794b9-959a-5492-94a2-2610778764c1","slug":"hiv1-dengue-replication","display_name":"HIV-1 and dengue virus replication in culture","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"323ae611-86cf-5006-a22c-1926297babae","stable_key":"e0801c92-7fd3-5cb2-82b7-dd82f010f3ed:ivermectin-hiv-dengue-replication-event","event_type":"observed_relationship","label":"Ivermectin inhibited replication of HIV-1 and dengue virus, both of which depend on importin alpha/beta nuclear import of HIV-1 integrase and dengue NS5 polymerase respectively.","description":"Ivermectin inhibited replication of HIV-1 and dengue virus, both of which depend on importin alpha/beta nuclear import of HIV-1 integrase and dengue NS5 polymerase respectively.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"416b9886-c6a5-5526-a8bf-b571a8d418bf","slug":"ivermectin","display_name":"Ivermectin","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ca1794b9-959a-5492-94a2-2610778764c1","slug":"hiv1-dengue-replication","display_name":"HIV-1 and dengue virus replication in culture","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b65fe2e8-46e5-58a8-9198-a4c4c713c08e","slug":"importin-alpha-beta","display_name":"Importin alpha/beta nuclear import complex","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"HIV-1 and dengue virus replication assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ivermectin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Antiviral activity in culture is attributed to the import mechanism by inference from the known import dependence of these viral proteins.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"HIV-1 and dengue virus replication assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Ivermectin inhibited replication of HIV-1 and dengue virus, both of which depend on importin alpha/beta nuclear import of HIV-1 integrase and dengue NS5 polymerase respectively.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. 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(2012). https://pubmed.ncbi.nlm.nih.gov/22417684/ DOI: 10.1042/BJ20120150\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"20818ddd-7b37-5226-a24b-7de007e80eb2","stable_key":"import-e0801c92-7fd3-5cb2-82b7-dd82f010f3ed","title":"Ivermectin: mechanism of action across parasite, host barrier and mammalian targets (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of sixteen primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Study-specific citations, concentrations, negative findings and limitations retained. 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