Component

Clamp glucose disposal after vanadyl sulfate

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. In the 16-person six-week type-2-diabetes trial, clamp glucose metabolism did not improve at 75 mg/day VOSO4; improvement occurred in three of five at 150 mg/day and four of eight at 300 mg/day.

    Vanadyl sulfate → Clamp glucose disposal after vanadyl sulfate source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Small placebo-lead-in dose-ranging trial; doses are sulfate preparation mass.
    limitations
    Responder counts are not a demonstrated group-wide clinical benefit; later pharmacokinetic analysis uses the same cohort.
    nutrient_topic
    Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Vanadium
    plain_language
    Some individuals responded while others did not.
    primary_references
    Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9

    Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19) · lines 374–380

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Small placebo-lead-in dose-ranging trial; doses are sulfate preparation mass. · source_derived_draft · unverified_draft

    ## vanadium-human-glucose-variable Some individuals responded while others did not. In the 16-person six-week type-2-diabetes trial, clamp glucose metabolism did not improve at 75 mg/day VOSO4; improvement occurred in three of five at 150 mg/day and four of eight at 300 mg/day. Model: Small placebo-lead-in dose-ranging trial; doses are sulfate preparation mass. Limitations: Responder counts are not a demonstrated group-wide clinical benefit; later pharmacokinetic analysis uses the same cohort. Evidence access: Primary abstract Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9
    Complete structured claim and evidence

  2. Total serum vanadium was not significantly correlated with insulin sensitivity in the pharmacokinetic analysis of the 16-person trial.

    Total vanadium in human serum → Clamp glucose disposal after vanadyl sulfate source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Reanalysis of the same six-week vanadyl cohort; serum/blood/urine measurements.
    limitations
    Not independent efficacy replication; unmeasured tissue pools remain a hypothesis.
    nutrient_topic
    Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Vanadium
    plain_language
    Total circulating metal is not a reliable proxy for the active tissue species.
    primary_references
    Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23982218/ · DOI 10.1039/c3mt00162h
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19) · lines 414–420

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Reanalysis of the same six-week vanadyl cohort; serum/blood/urine measurements. · source_derived_draft · unverified_draft

    ## vanadium-human-serum-marker Total circulating metal is not a reliable proxy for the active tissue species. Total serum vanadium was not significantly correlated with insulin sensitivity in the pharmacokinetic analysis of the 16-person trial. Model: Reanalysis of the same six-week vanadyl cohort; serum/blood/urine measurements. Limitations: Not independent efficacy replication; unmeasured tissue pools remain a hypothesis. Evidence access: Primary full text Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23982218/ · DOI 10.1039/c3mt00162h
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards