{"id":"7bb049c5-4db9-54f6-8e6c-a27ce54edbfc","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-glucose-variable","predicate":"has_variable_effect","statement":"In the 16-person six-week type-2-diabetes trial, clamp glucose metabolism did not improve at 75 mg/day VOSO4; improvement occurred in three of five at 150 mg/day and four of eight at 300 mg/day.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4eee023d-b88f-5384-92a7-ac36e86def71","mechanism_event_label":"Some individuals responded while others did not.","subject":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"object":{"id":"91bf488d-d2c1-575a-819c-b44f385975a1","slug":"human-vanadyl-clamp-glucose-disposal","display_name":"Clamp glucose disposal after vanadyl sulfate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4eee023d-b88f-5384-92a7-ac36e86def71","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-glucose-variable-event","event_type":"observed_relationship","label":"Some individuals responded while others did not.","description":"In the 16-person six-week type-2-diabetes trial, clamp glucose metabolism did not improve at 75 mg/day VOSO4; improvement occurred in three of five at 150 mg/day and four of eight at 300 mg/day.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"91bf488d-d2c1-575a-819c-b44f385975a1","slug":"human-vanadyl-clamp-glucose-disposal","display_name":"Clamp glucose disposal after vanadyl sulfate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small placebo-lead-in dose-ranging trial; doses are sulfate preparation mass.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Responder counts are not a demonstrated group-wide clinical benefit; later pharmacokinetic analysis uses the same cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Some individuals responded while others did not.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f368e020-b88a-5293-9435-5a310e209e73","evidence_kind":"source_excerpt","locator":"Lines 374-380","start_line":374,"end_line":380,"excerpt":"## vanadium-human-glucose-variable\nSome individuals responded while others did not.\nIn the 16-person six-week type-2-diabetes trial, clamp glucose metabolism did not improve at 75 mg/day VOSO4; improvement occurred in three of five at 150 mg/day and four of eight at 300 mg/day.\nModel: Small placebo-lead-in dose-ranging trial; doses are sulfate preparation mass.\nLimitations: Responder counts are not a demonstrated group-wide clinical benefit; later pharmacokinetic analysis uses the same cohort.\nEvidence access: Primary abstract\nMetabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9","model_system":"Small placebo-lead-in dose-ranging trial; doses are sulfate preparation mass.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"d36b30d972e756ca4d19b66f976980e206c65025bd4bbf4c127c17320bd019c2","revision_id":"70d42967-8032-5627-8670-f59841735e89","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}