Component

Human plasma lutein concentration

Human plasma lutein concentration. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Lutein rose 207% with the high-fat spread versus 88% with the low-fat spread during lutein-ester supplementation.

    High-fat meal with lutein esters in the 2000 crossover study → Human plasma lutein concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lutein-research/10799382.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "68c85cb7c391b6bffddcdc9ca0620c8db353400604353ce62873fe74501a0868", "start_char": 0, "end_char": 1602, "text_sha256": "68c85cb7c391b6bffddcdc9ca0620c8db353400604353ce62873fe74501a0868"}
    experimental_model
    Random-sequence crossover supplementation
    exposure
    Lutein esters providing 8 mg lutein; 3 versus 36 g meal fat; seven-day periods
    limitations
    Formulation-specific short-term response; not a universal minimum fat requirement.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Human volunteers in four groups of 14–15
    plain_language
    Meal fat changed uptake from this ester formulation.
    primary_references
    [lutein-p10799382] Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. (2000). https://pubmed.ncbi.nlm.nih.gov/10799382/ DOI: 10.1093/ajcn/71.5.1187
    tissue_or_cell_type
    Plasma carotenoid response

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 580–591

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Random-sequence crossover supplementation · source_derived_draft · unverified_draft

    ### lutein-dietary-fat Lutein rose 207% with the high-fat spread versus 88% with the low-fat spread during lutein-ester supplementation. Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: Meal fat changed uptake from this ester formulation. organism: Human volunteers in four groups of 14–15 tissue_or_cell_type: Plasma carotenoid response experimental_model: Random-sequence crossover supplementation limitations: Formulation-specific short-term response; not a universal minimum fat requirement. exposure: Lutein esters providing 8 mg lutein; 3 versus 36 g meal fat; seven-day periods evidence_span: {"source_cache": "artifacts/lutein-research/10799382.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "68c85cb7c391b6bffddcdc9ca0620c8db353400604353ce62873fe74501a0868", "start_char": 0, "end_char": 1602, "text_sha256": "68c85cb7c391b6bffddcdc9ca0620c8db353400604353ce62873fe74501a0868"} [lutein-p10799382] Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. (2000). https://pubmed.ncbi.nlm.nih.gov/10799382/ DOI: 10.1093/ajcn/71.5.1187
    Complete structured claim and evidence

  2. The high-lutein/zeaxanthin diet increased circulating xanthophylls approximately two- to threefold in both groups.

    Lutein → Human plasma lutein concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lutein-research/17344498.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "582744e7beef9ad8341bf862c9d344c1f188e6087676bcaa4c32679547fffe79", "start_char": 0, "end_char": 1666, "text_sha256": "582744e7beef9ad8341bf862c9d344c1f188e6087676bcaa4c32679547fffe79"}
    experimental_model
    Controlled low- then high-xanthophyll diet
    exposure
    About 1.1 mg/day L+Z for two weeks then 11 mg/day for four weeks
    limitations
    Small dietary study; circulating distribution is not retinal delivery or an intervention to raise HDL cholesterol.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Seven AMD patients and five controls
    plain_language
    Both groups absorbed the higher dietary supply.
    primary_references
    [lutein-p17344498] Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration. (2007). https://pubmed.ncbi.nlm.nih.gov/17344498/ DOI: 10.1093/ajcn/85.3.762
    tissue_or_cell_type
    Plasma and separated lipoprotein fractions

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 606–617

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled low- then high-xanthophyll diet · source_derived_draft · unverified_draft

    ### lutein-human-diet-plasma The high-lutein/zeaxanthin diet increased circulating xanthophylls approximately two- to threefold in both groups. Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: Both groups absorbed the higher dietary supply. organism: Seven AMD patients and five controls tissue_or_cell_type: Plasma and separated lipoprotein fractions experimental_model: Controlled low- then high-xanthophyll diet limitations: Small dietary study; circulating distribution is not retinal delivery or an intervention to raise HDL cholesterol. exposure: About 1.1 mg/day L+Z for two weeks then 11 mg/day for four weeks evidence_span: {"source_cache": "artifacts/lutein-research/17344498.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "582744e7beef9ad8341bf862c9d344c1f188e6087676bcaa4c32679547fffe79", "start_char": 0, "end_char": 1666, "text_sha256": "582744e7beef9ad8341bf862c9d344c1f188e6087676bcaa4c32679547fffe79"} [lutein-p17344498] Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration. (2007). https://pubmed.ncbi.nlm.nih.gov/17344498/ DOI: 10.1093/ajcn/85.3.762
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards