Component

Human nerve growth factor / NGF

Species, preparation, dose and limitations are retained on linked claims.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Hericium erinaceus ethanol extract increased NGF mRNA and secretion through JNK/c-Jun/c-Fos signaling in human 1321N1 cells.

    Hericium erinaceus ethanol extract used in the 2008 NGF study → NGF expression and secretion in human 1321N1 astrocytoma cells source_derived_draftungraded
    Experimental context and source evidence
    dose
    Concentration series of ethanol extract
    duration
    Acute cell assay; 7 days in mice
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    Human 1321N1 astrocytoma cells; 5% dry-mushroom-feed mouse arm
    limitations
    The active extract constituents were not identified, and transformed cells do not establish clinical neurotrophic effects.
    nutrient_topic
    Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Hericenones and erinacines
    organism
    Human 1321N1 astrocytoma cells; 5% dry-mushroom-feed mouse arm
    plain_language
    Hericium erinaceus ethanol extract increased NGF mRNA and secretion through JNK/c-Jun/c-Fos signaling in human 1321N1 cells.
    primary_references
    Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18758067/ DOI: 10.1248/bpb.31.1727
    route
    In vitro; oral food powder in mice
    tissue
    NGF expression, secretion and JNK signaling

    Hericenones & Erinacines: mechanism of action and interactions (2026-09-20) · lines 11–20

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Human 1321N1 astrocytoma cells; 5% dry-mushroom-feed mouse arm · source_derived_draft · unverified_draft

    ## hericenones-erinacines-extract-ngf Hericium erinaceus ethanol extract increased NGF mRNA and secretion through JNK/c-Jun/c-Fos signaling in human 1321N1 cells. Model/species: Human 1321N1 astrocytoma cells; 5% dry-mushroom-feed mouse arm Tissue/system: NGF expression, secretion and JNK signaling Exposure: Concentration series of ethanol extract Route: In vitro; oral food powder in mice Duration: Acute cell assay; 7 days in mice Limits: The active extract constituents were not identified, and transformed cells do not establish clinical neurotrophic effects. Primary reference: Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18758067/ DOI: 10.1248/bpb.31.1727 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

  2. One microgram/mL aqueous Hericium extract combined with 10 ng/mL NGF produced the largest neurite-outgrowth response, while the extract did not protect against the oxidative-stress challenge.

    Hericium erinaceus aqueous extract used in the 2013 neurite study → NGF-induced neurite outgrowth in NG108-15 cells source_derived_draftungraded
    Experimental context and source evidence
    dose
    Aqueous extract 1 microgram/mL with NGF 10 ng/mL
    duration
    Cell differentiation interval
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    NG108-15 neuroblastoma-glioma cells
    limitations
    A whole aqueous extract plus exogenous NGF is not evidence for a specific hericenone or erinacine, and the oxidative-stress result was null.
    nutrient_topic
    Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Hericenones and erinacines
    organism
    NG108-15 neuroblastoma-glioma cells
    plain_language
    One microgram/mL aqueous Hericium extract combined with 10 ng/mL NGF produced the largest neurite-outgrowth response, while the extract did not protect against the oxidative-stress challenge.
    primary_references
    Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. (2013). https://pubmed.ncbi.nlm.nih.gov/24266378/ DOI: 10.1615/intjmedmushr.v15.i6.30
    route
    In vitro
    tissue
    Neurite outgrowth and oxidative-stress survival

    Hericenones & Erinacines: mechanism of action and interactions (2026-09-20) · lines 33–42

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · NG108-15 neuroblastoma-glioma cells · source_derived_draft · unverified_draft

    ## hericenones-erinacines-extract-ngf-synergy One microgram/mL aqueous Hericium extract combined with 10 ng/mL NGF produced the largest neurite-outgrowth response, while the extract did not protect against the oxidative-stress challenge. Model/species: NG108-15 neuroblastoma-glioma cells Tissue/system: Neurite outgrowth and oxidative-stress survival Exposure: Aqueous extract 1 microgram/mL with NGF 10 ng/mL Route: In vitro Duration: Cell differentiation interval Limits: A whole aqueous extract plus exogenous NGF is not evidence for a specific hericenone or erinacine, and the oxidative-stress result was null. Primary reference: Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. (2013). https://pubmed.ncbi.nlm.nih.gov/24266378/ DOI: 10.1615/intjmedmushr.v15.i6.30 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

  3. K252a partially blocked hericenone-E-associated neuritogenesis, while hericenone E increased NGF secretion and ERK/Akt phosphorylation.

    K252a Trk-family inhibitor → Hericenone E potentiation of NGF-induced PC12 neuritogenesis source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    dose
    Hericenone E with low NGF and K252a
    duration
    Differentiation assay
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    Rat PC12 pheochromocytoma cells
    limitations
    Partial blockade suggests Trk involvement but not sole dependence; PC12 exposure does not establish human brain target engagement.
    nutrient_topic
    Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Hericenones and erinacines
    organism
    Rat PC12 pheochromocytoma cells
    plain_language
    K252a partially blocked hericenone-E-associated neuritogenesis, while hericenone E increased NGF secretion and ERK/Akt phosphorylation.
    primary_references
    Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. (2014). https://pubmed.ncbi.nlm.nih.gov/25288148/ DOI: 10.1039/c4fo00452c
    route
    In vitro
    tissue
    NGF secretion, neurite outgrowth, ERK and Akt
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Hericenones & Erinacines: mechanism of action and interactions (2026-09-20) · lines 44–53

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Rat PC12 pheochromocytoma cells · source_derived_draft · unverified_draft

    ## hericenones-erinacines-hericenone-e-ngf K252a partially blocked hericenone-E-associated neuritogenesis, while hericenone E increased NGF secretion and ERK/Akt phosphorylation. Model/species: Rat PC12 pheochromocytoma cells Tissue/system: NGF secretion, neurite outgrowth, ERK and Akt Exposure: Hericenone E with low NGF and K252a Route: In vitro Duration: Differentiation assay Limits: Partial blockade suggests Trk involvement but not sole dependence; PC12 exposure does not establish human brain target engagement. Primary reference: Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. (2014). https://pubmed.ncbi.nlm.nih.gov/25288148/ DOI: 10.1039/c4fo00452c Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards