Component
Hericenone E potentiation of NGF-induced PC12 neuritogenesis
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
K252a partially blocked hericenone-E-associated neuritogenesis, while hericenone E increased NGF secretion and ERK/Akt phosphorylation.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- dose
- Hericenone E with low NGF and K252a
- duration
- Differentiation assay
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Rat PC12 pheochromocytoma cells
- limitations
- Partial blockade suggests Trk involvement but not sole dependence; PC12 exposure does not establish human brain target engagement.
- nutrient_topic
- Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Hericenones and erinacines
- organism
- Rat PC12 pheochromocytoma cells
- plain_language
- K252a partially blocked hericenone-E-associated neuritogenesis, while hericenone E increased NGF secretion and ERK/Akt phosphorylation.
- primary_references
- Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. (2014). https://pubmed.ncbi.nlm.nih.gov/25288148/ DOI: 10.1039/c4fo00452c
- route
- In vitro
- tissue
- NGF secretion, neurite outgrowth, ERK and Akt
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Hericenones & Erinacines: mechanism of action and interactions (2026-09-20) · lines 44–53
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Rat PC12 pheochromocytoma cells · source_derived_draft · unverified_draft
## hericenones-erinacines-hericenone-e-ngf K252a partially blocked hericenone-E-associated neuritogenesis, while hericenone E increased NGF secretion and ERK/Akt phosphorylation. Model/species: Rat PC12 pheochromocytoma cells Tissue/system: NGF secretion, neurite outgrowth, ERK and Akt Exposure: Hericenone E with low NGF and K252a Route: In vitro Duration: Differentiation assay Limits: Partial blockade suggests Trk involvement but not sole dependence; PC12 exposure does not establish human brain target engagement. Primary reference: Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. (2014). https://pubmed.ncbi.nlm.nih.gov/25288148/ DOI: 10.1039/c4fo00452c Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.