Component
NGF expression and secretion in human 1321N1 astrocytoma cells
Species, preparation, dose and limitations are retained on linked claims.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Hericium erinaceus ethanol extract increased NGF mRNA and secretion through JNK/c-Jun/c-Fos signaling in human 1321N1 cells.
Experimental context and source evidence
- dose
- Concentration series of ethanol extract
- duration
- Acute cell assay; 7 days in mice
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Human 1321N1 astrocytoma cells; 5% dry-mushroom-feed mouse arm
- limitations
- The active extract constituents were not identified, and transformed cells do not establish clinical neurotrophic effects.
- nutrient_topic
- Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Hericenones and erinacines
- organism
- Human 1321N1 astrocytoma cells; 5% dry-mushroom-feed mouse arm
- plain_language
- Hericium erinaceus ethanol extract increased NGF mRNA and secretion through JNK/c-Jun/c-Fos signaling in human 1321N1 cells.
- primary_references
- Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18758067/ DOI: 10.1248/bpb.31.1727
- route
- In vitro; oral food powder in mice
- tissue
- NGF expression, secretion and JNK signaling
Hericenones & Erinacines: mechanism of action and interactions (2026-09-20) · lines 11–20
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Human 1321N1 astrocytoma cells; 5% dry-mushroom-feed mouse arm · source_derived_draft · unverified_draft
## hericenones-erinacines-extract-ngf Hericium erinaceus ethanol extract increased NGF mRNA and secretion through JNK/c-Jun/c-Fos signaling in human 1321N1 cells. Model/species: Human 1321N1 astrocytoma cells; 5% dry-mushroom-feed mouse arm Tissue/system: NGF expression, secretion and JNK signaling Exposure: Concentration series of ethanol extract Route: In vitro; oral food powder in mice Duration: Acute cell assay; 7 days in mice Limits: The active extract constituents were not identified, and transformed cells do not establish clinical neurotrophic effects. Primary reference: Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18758067/ DOI: 10.1248/bpb.31.1727 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidencePurified hericenones C, D and E failed to promote NGF gene expression in the 1321N1 assay that responded to the whole extract.
Experimental context and source evidence
- dose
- Purified hericenones C, D and E
- duration
- Acute
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Human 1321N1 astrocytoma cells
- limitations
- This source-specific null prevents assigning the extract's NGF induction to those three molecules; other assays may differ.
- nutrient_topic
- Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Hericenones and erinacines
- organism
- Human 1321N1 astrocytoma cells
- plain_language
- Purified hericenones C, D and E failed to promote NGF gene expression in the 1321N1 assay that responded to the whole extract.
- primary_references
- Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18758067/ DOI: 10.1248/bpb.31.1727
- route
- In vitro
- tissue
- NGF gene expression
Hericenones & Erinacines: mechanism of action and interactions (2026-09-20) · lines 22–31
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Human 1321N1 astrocytoma cells · source_derived_draft · unverified_draft
## hericenones-erinacines-hericenone-cde-null Purified hericenones C, D and E failed to promote NGF gene expression in the 1321N1 assay that responded to the whole extract. Model/species: Human 1321N1 astrocytoma cells Tissue/system: NGF gene expression Exposure: Purified hericenones C, D and E Route: In vitro Duration: Acute Limits: This source-specific null prevents assigning the extract's NGF induction to those three molecules; other assays may differ. Primary reference: Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. (2008). https://pubmed.ncbi.nlm.nih.gov/18758067/ DOI: 10.1248/bpb.31.1727 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.