Component
cAMP phosphodiesterase activity in human neutrophil lysates
Mixed lysate enzyme activity; this assay alone does not establish PDE4D-selective inhibition.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Adding 6-gingerol reduced human neutrophil lysate cAMP-PDE activity by about 40 percent.
Experimental context and source evidence
- dose
- 6-Gingerol 10 micromolar; rolipram 0.1 micromolar comparator
- duration
- 1 h at 37 degrees C
- evidence_access
- Primary open full text, results, figure legends and methods, plus PubMed metadata.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Lysates of human donor neutrophils
- limitations
- Mixed cAMP-PDE activity was measured; similarity to rolipram does not establish isoform selectivity.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Lysates of human donor neutrophils
- plain_language
- Adding 6-gingerol reduced human neutrophil lysate cAMP-PDE activity by about 40 percent.
- primary_references
- Antineutrophil properties of natural gingerols in models of lupus. (2021). https://pubmed.ncbi.nlm.nih.gov/33373329/ DOI: 10.1172/jci.insight.138385
- route
- Ex vivo lysate assay
- tissue
- Neutrophil enzyme preparation
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 448–457
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Lysates of human donor neutrophils · source_derived_draft · unverified_draft
## gingerols-6-neutrophil-pde Adding 6-gingerol reduced human neutrophil lysate cAMP-PDE activity by about 40 percent. Model/species: Lysates of human donor neutrophils Tissue: Neutrophil enzyme preparation Exposure: 6-Gingerol 10 micromolar; rolipram 0.1 micromolar comparator Route: Ex vivo lysate assay Duration: 1 h at 37 degrees C Limits: Mixed cAMP-PDE activity was measured; similarity to rolipram does not establish isoform selectivity. Primary reference: Antineutrophil properties of natural gingerols in models of lupus. (2021). https://pubmed.ncbi.nlm.nih.gov/33373329/ DOI: 10.1172/jci.insight.138385 Access: Primary open full text, results, figure legends and methods, plus PubMed metadata.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.