Component
Isoleucine shortage during human MSUD dietary treatment
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
A critically ill newborn with MSUD developed corneal epithelial loss with skin and intestinal symptoms during isolated isoleucine deficiency.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Single infant case during intensive metabolic dietary treatment.
- limitations
- Case attribution does not define a universal plasma threshold or the molecular epithelial mechanism.
- nutrient_topic
- L-Isoleucine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Isoleucine
- plain_language
- Inadequate supply can affect more than muscle or growth.
- primary_references
- Corneal deepithelialization caused by acute deficiency of isoleucine during treatment of a patient with maple syrup urine disease. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8741119/ · DOI 10.1111/j.1600-0420.1996.tb00386.x
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
L-Isoleucine: transport, translation, catabolism and cross-nutrient mechanisms (2026-09-19) · lines 330–336
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Single infant case during intensive metabolic dietary treatment. · source_derived_draft · unverified_draft
## isoleucine-shortage-cornea Inadequate supply can affect more than muscle or growth. A critically ill newborn with MSUD developed corneal epithelial loss with skin and intestinal symptoms during isolated isoleucine deficiency. Model: Single infant case during intensive metabolic dietary treatment. Limitations: Case attribution does not define a universal plasma threshold or the molecular epithelial mechanism. Evidence access: Primary abstract Corneal deepithelialization caused by acute deficiency of isoleucine during treatment of a patient with maple syrup urine disease. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8741119/ · DOI 10.1111/j.1600-0420.1996.tb00386.x
Complete structured claim and evidenceAn infant on MSUD treatment developed dermatitis, diarrhea and hair loss associated with isoleucine deficiency; skin lesions resolved after combined dietary correction and topical treatment.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Human case report; isoleucine replacement, leucine restriction and topical mometasone used together.
- limitations
- Combined treatment prevents assigning the entire response to one intervention; not a general dermatitis diagnosis.
- nutrient_topic
- L-Isoleucine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Isoleucine
- plain_language
- Restricting a breakdown substrate too far can damage tissues that still need it.
- primary_references
- Acrodermatitis dysmetabolica secondary to isoleucine deficiency in infant with maple syrup urine disease. · 2023 · https://pubmed.ncbi.nlm.nih.gov/38327590/ · DOI 10.4081/dr.2023.9750
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
L-Isoleucine: transport, translation, catabolism and cross-nutrient mechanisms (2026-09-19) · lines 322–328
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human case report; isoleucine replacement, leucine restriction and topical mometasone used together. · source_derived_draft · unverified_draft
## isoleucine-shortage-skin Restricting a breakdown substrate too far can damage tissues that still need it. An infant on MSUD treatment developed dermatitis, diarrhea and hair loss associated with isoleucine deficiency; skin lesions resolved after combined dietary correction and topical treatment. Model: Human case report; isoleucine replacement, leucine restriction and topical mometasone used together. Limitations: Combined treatment prevents assigning the entire response to one intervention; not a general dermatitis diagnosis. Evidence access: Primary abstract Acrodermatitis dysmetabolica secondary to isoleucine deficiency in infant with maple syrup urine disease. · 2023 · https://pubmed.ncbi.nlm.nih.gov/38327590/ · DOI 10.4081/dr.2023.9750
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.