{"id":"950d1276-2023-5aad-8934-a4714795e9ed","stable_key":"09b23d0d-35e2-51ff-b1aa-b4f9227e4fa2:isoleucine-shortage-skin","predicate":"associates_with","statement":"An infant on MSUD treatment developed dermatitis, diarrhea and hair loss associated with isoleucine deficiency; skin lesions resolved after combined dietary correction and topical treatment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c06781e8-9434-57db-82ee-6ebb390defc5","mechanism_event_label":"Restricting a breakdown substrate too far can damage tissues that still need it.","subject":{"id":"06716756-0aeb-5a53-b11a-934fc4c49973","slug":"human-msud-treatment-isoleucine-shortage","display_name":"Isoleucine shortage during human MSUD dietary treatment","entity_type_key":"cellular_process"},"object":{"id":"792e1118-52e0-5ca6-b185-717bf1d7e1fd","slug":"human-isoleucine-shortage-epithelial-injury","display_name":"Epithelial injury during isoleucine shortage","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c06781e8-9434-57db-82ee-6ebb390defc5","stable_key":"09b23d0d-35e2-51ff-b1aa-b4f9227e4fa2:isoleucine-shortage-skin-event","event_type":"observed_relationship","label":"Restricting a breakdown substrate too far can damage tissues that still need it.","description":"An infant on MSUD treatment developed dermatitis, diarrhea and hair loss associated with isoleucine deficiency; 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