{"id":"c384c44a-c8ec-524a-a018-fa3af4c2833b","stable_key":"09b23d0d-35e2-51ff-b1aa-b4f9227e4fa2:isoleucine-shortage-cornea","predicate":"associates_with","statement":"A critically ill newborn with MSUD developed corneal epithelial loss with skin and intestinal symptoms during isolated isoleucine deficiency.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0b3577be-a286-5ac1-a9c5-17401b7e2dc5","mechanism_event_label":"Inadequate supply can affect more than muscle or growth.","subject":{"id":"06716756-0aeb-5a53-b11a-934fc4c49973","slug":"human-msud-treatment-isoleucine-shortage","display_name":"Isoleucine shortage during human MSUD dietary treatment","entity_type_key":"cellular_process"},"object":{"id":"ed6fc2e6-5bfe-5d45-914f-c8e7b01c92ec","slug":"human-isoleucine-shortage-corneal-injury","display_name":"Corneal epithelial loss during isoleucine shortage","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0b3577be-a286-5ac1-a9c5-17401b7e2dc5","stable_key":"09b23d0d-35e2-51ff-b1aa-b4f9227e4fa2:isoleucine-shortage-cornea-event","event_type":"observed_relationship","label":"Inadequate supply can affect more than muscle or growth.","description":"A critically ill newborn with MSUD developed corneal epithelial loss with skin and intestinal symptoms during isolated isoleucine deficiency.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06716756-0aeb-5a53-b11a-934fc4c49973","slug":"human-msud-treatment-isoleucine-shortage","display_name":"Isoleucine shortage during human MSUD dietary treatment","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ed6fc2e6-5bfe-5d45-914f-c8e7b01c92ec","slug":"human-isoleucine-shortage-corneal-injury","display_name":"Corneal epithelial loss during isoleucine shortage","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c85b327e-f132-5d9a-8e4b-c2976fcc0373","slug":"isoleucine","display_name":"L-Isoleucine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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