Component
Alanine-evoked glucagon in isolated human and mouse islets
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Leucine suppressed alanine- and arginine-stimulated glucagon secretion in isolated human and mouse islets under the tested low-glucose conditions.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human and mouse islet perifusion; low-glucose amino-acid challenges.
- limitations
- Mixed-species functional observation, not a human supplementation trial; nutrient concentrations and glucose state determine interpretation.
- nutrient_topic
- L-Alanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Alanine
- plain_language
- One amino acid can reduce the hormone response to another.
- primary_references
- Leucine Suppresses α-Cell cAMP and Glucagon Secretion via a Combination of Cell-Intrinsic and Islet Paracrine Signaling. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38870025/ · DOI 10.2337/db23-1013
L-Alanine: carbon, nitrogen, protein synthesis and cross-nutrient mechanisms (2026-09-19) · lines 344–350
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human and mouse islet perifusion; low-glucose amino-acid challenges. · source_derived_draft · unverified_draft
## alanine-leucine-glucagon One amino acid can reduce the hormone response to another. Leucine suppressed alanine- and arginine-stimulated glucagon secretion in isolated human and mouse islets under the tested low-glucose conditions. Model: Human and mouse islet perifusion; low-glucose amino-acid challenges. Limitations: Mixed-species functional observation, not a human supplementation trial; nutrient concentrations and glucose state determine interpretation. Evidence access: Primary abstract Leucine Suppresses α-Cell cAMP and Glucagon Secretion via a Combination of Cell-Intrinsic and Islet Paracrine Signaling. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38870025/ · DOI 10.2337/db23-1013
Complete structured claim and evidence
Where it participates (unsigned role)
Leucine reduced mouse alpha-cell cAMP even when beta/delta-cell paracrine signaling was limited; cyanide blocked the inhibitory response, supporting mitochondrial-metabolism dependence.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse islet and dispersed-cell experiments; paracrine blockers and metabolic inhibitors.
- limitations
- Cyanide is broad; the experiment does not identify one unique mitochondrial enzyme as the leucine target.
- nutrient_topic
- L-Alanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Alanine
- plain_language
- Part of the suppression arose inside the glucagon-producing cell.
- primary_references
- Leucine Suppresses α-Cell cAMP and Glucagon Secretion via a Combination of Cell-Intrinsic and Islet Paracrine Signaling. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38870025/ · DOI 10.2337/db23-1013
L-Alanine: carbon, nitrogen, protein synthesis and cross-nutrient mechanisms (2026-09-19) · lines 352–358
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse islet and dispersed-cell experiments; paracrine blockers and metabolic inhibitors. · source_derived_draft · unverified_draft
## alanine-leucine-alpha-camp Part of the suppression arose inside the glucagon-producing cell. Leucine reduced mouse alpha-cell cAMP even when beta/delta-cell paracrine signaling was limited; cyanide blocked the inhibitory response, supporting mitochondrial-metabolism dependence. Model: Mouse islet and dispersed-cell experiments; paracrine blockers and metabolic inhibitors. Limitations: Cyanide is broad; the experiment does not identify one unique mitochondrial enzyme as the leucine target. Evidence access: Primary abstract Leucine Suppresses α-Cell cAMP and Glucagon Secretion via a Combination of Cell-Intrinsic and Islet Paracrine Signaling. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38870025/ · DOI 10.2337/db23-1013
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.