Component
Human milk total thiamine concentration
Independent biological entity. Read linked claims for experimental scope and context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
All three supplementation groups had higher milk total thiamine than placebo, without significant differences between active groups.
Experimental context and source evidence
- experimental_model
- 335 mother-infant dyads; 22-week intervention.
- exposure
- Maternal 0, 1.2, 2.4 or 10 mg/day thiamine from weeks 2-24 postpartum; study exposures only.
- limitations
- Milk concentration alone is not an infant clinical outcome; model-derived optimal-dose estimate had wide uncertainty.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Homo sapiens
- plain_language
- Maternal B1 intake changed the infant supply route, with a flattening response across the tested active doses.
- primary_references
- [b1-gallant2021] Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial (2021). https://pubmed.ncbi.nlm.nih.gov/33829271/ DOI: 10.1093/ajcn/nqab052
- tissue_or_cell_type
- Human milk
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1807–1817
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 335 mother-infant dyads; 22-week intervention. · source_derived_draft · unverified_draft
### b1-maternal-intake-milk All three supplementation groups had higher milk total thiamine than placebo, without significant differences between active groups. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Maternal B1 intake changed the infant supply route, with a flattening response across the tested active doses. organism: Homo sapiens tissue_or_cell_type: Human milk experimental_model: 335 mother-infant dyads; 22-week intervention. limitations: Milk concentration alone is not an infant clinical outcome; model-derived optimal-dose estimate had wide uncertainty. exposure: Maternal 0, 1.2, 2.4 or 10 mg/day thiamine from weeks 2-24 postpartum; study exposures only. [b1-gallant2021] Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial (2021). https://pubmed.ncbi.nlm.nih.gov/33829271/ DOI: 10.1093/ajcn/nqab052
Complete structured claim and evidence
Where it participates (unsigned role)
Infant whole-blood ThDP was higher in all maternal supplementation groups than placebo at 24 weeks.
Experimental context and source evidence
- experimental_model
- Same trial; infants mostly breastfed.
- exposure
- Maternal 0, 1.2, 2.4 or 10 mg/day thiamine from weeks 2-24 postpartum; study exposures only.
- limitations
- No direct measurement of each tissue cofactor pool or mortality benefit.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Homo sapiens
- plain_language
- Improving maternal intake changed an infant blood marker.
- primary_references
- [b1-gallant2021] Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial (2021). https://pubmed.ncbi.nlm.nih.gov/33829271/ DOI: 10.1093/ajcn/nqab052
- tissue_or_cell_type
- Infant blood
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1819–1829
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Same trial; infants mostly breastfed. · source_derived_draft · unverified_draft
### b1-maternal-intake-infant-thdp Infant whole-blood ThDP was higher in all maternal supplementation groups than placebo at 24 weeks. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Improving maternal intake changed an infant blood marker. organism: Homo sapiens tissue_or_cell_type: Infant blood experimental_model: Same trial; infants mostly breastfed. limitations: No direct measurement of each tissue cofactor pool or mortality benefit. exposure: Maternal 0, 1.2, 2.4 or 10 mg/day thiamine from weeks 2-24 postpartum; study exposures only. [b1-gallant2021] Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial (2021). https://pubmed.ncbi.nlm.nih.gov/33829271/ DOI: 10.1093/ajcn/nqab052
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.