{"id":"0f465409-a291-52e7-93a8-a120582a705c","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-maternal-intake-milk","predicate":"maternal_supplementation_increases","statement":"All three supplementation groups had higher milk total thiamine than placebo, without significant differences between active groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3f8276f3-0af9-5f70-b055-e86b5207c329","mechanism_event_label":"Maternal B1 intake changed the infant supply route, with a flattening response across the tested active doses.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"995ca269-c95f-5442-a672-d2184732bad6","slug":"human-milk-thiamine-concentration","display_name":"Human milk total thiamine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3f8276f3-0af9-5f70-b055-e86b5207c329","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-maternal-intake-milk-event","event_type":"observed_intervention","label":"Maternal B1 intake changed the infant supply route, with a flattening response across the tested active doses.","description":"All three supplementation groups had higher milk total thiamine than placebo, without significant differences between active groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"187db168-8028-5ce6-9f8b-4bc61ebad1a0","slug":"thiamine-diphosphate","display_name":"Thiamine diphosphate","entity_type_key":"small_molecule"},"role":"one_measured_milk_form","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"995ca269-c95f-5442-a672-d2184732bad6","slug":"human-milk-thiamine-concentration","display_name":"Human milk total thiamine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"335 mother-infant dyads; 22-week intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Maternal 0, 1.2, 2.4 or 10 mg/day thiamine from weeks 2-24 postpartum; study exposures only.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Milk concentration alone is not an infant clinical outcome; model-derived optimal-dose estimate had wide uncertainty.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Maternal B1 intake changed the infant supply route, with a flattening response across the tested active doses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-gallant2021] Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial (2021). https://pubmed.ncbi.nlm.nih.gov/33829271/ DOI: 10.1093/ajcn/nqab052","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human milk","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d8eb8da7-49a3-5e87-917d-d217c795fae4","evidence_kind":"source_excerpt","locator":"Lines 1807-1817","start_line":1807,"end_line":1817,"excerpt":"### b1-maternal-intake-milk\nAll three supplementation groups had higher milk total thiamine than placebo, without significant differences between active groups.\nCondition category: normal\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Maternal B1 intake changed the infant supply route, with a flattening response across the tested active doses.\norganism: Homo sapiens\ntissue_or_cell_type: Human milk\nexperimental_model: 335 mother-infant dyads; 22-week intervention.\nlimitations: Milk concentration alone is not an infant clinical outcome; model-derived optimal-dose estimate had wide uncertainty.\nexposure: Maternal 0, 1.2, 2.4 or 10 mg/day thiamine from weeks 2-24 postpartum; study exposures only.\n[b1-gallant2021] Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial (2021). https://pubmed.ncbi.nlm.nih.gov/33829271/ DOI: 10.1093/ajcn/nqab052","model_system":"335 mother-infant dyads; 22-week intervention.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-gallant2021] Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial (2021). https://pubmed.ncbi.nlm.nih.gov/33829271/ DOI: 10.1093/ajcn/nqab052","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}