Component

Human IL-10-positive regulatory B-cell differentiation

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Myricetin reduced IL-10-positive B-cell frequencies and IL-10 secretion after 72-hour CpGC stimulation without reducing B-cell viability.

    Myricetin → Human IL-10-positive regulatory B-cell differentiation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Primary human B cells; methods specify 10 micromolar myricetin.
    limitations
    Extended Data figure caption in retrieved text says 10 mM, conflicting with methods; use methods dose provisionally and retain the reporting discrepancy. D9-only results are not assigned to myricetin.
    nutrient_topic
    Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Myricetin
    plain_language
    An immune-suppressing B-cell population also depends on redox machinery.
    primary_references
    Thioredoxin is a metabolic rheostat controlling regulatory B cells. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38553615/ · DOI 10.1038/s41590-024-01798-w

    Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 292–298

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary human B cells; methods specify 10 micromolar myricetin. · source_derived_draft · unverified_draft

    ## myricetin-breg-myricetin An immune-suppressing B-cell population also depends on redox machinery. Myricetin reduced IL-10-positive B-cell frequencies and IL-10 secretion after 72-hour CpGC stimulation without reducing B-cell viability. Model: Primary human B cells; methods specify 10 micromolar myricetin. Limitations: Extended Data figure caption in retrieved text says 10 mM, conflicting with methods; use methods dose provisionally and retain the reporting discrepancy. D9-only results are not assigned to myricetin. Evidence access: Primary full text Thioredoxin is a metabolic rheostat controlling regulatory B cells. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38553615/ · DOI 10.1038/s41590-024-01798-w
    Complete structured claim and evidence

  2. CRISPR–Cas9 silencing of TXN1 reduced IL-10-positive B-cell frequencies after CpGC stimulation.

    TXN1 → Human IL-10-positive regulatory B-cell differentiation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Primary human B cells; 72-hour stimulation.
    limitations
    Supports machinery dependence, not selective drug targeting or evidence that a supplement causes autoimmunity.
    nutrient_topic
    Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Myricetin
    plain_language
    Removing one component weakens the same immune program.
    primary_references
    Thioredoxin is a metabolic rheostat controlling regulatory B cells. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38553615/ · DOI 10.1038/s41590-024-01798-w
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 308–314

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary human B cells; 72-hour stimulation. · source_derived_draft · unverified_draft

    ## myricetin-breg-silencing-txn1 Removing one component weakens the same immune program. CRISPR–Cas9 silencing of TXN1 reduced IL-10-positive B-cell frequencies after CpGC stimulation. Model: Primary human B cells; 72-hour stimulation. Limitations: Supports machinery dependence, not selective drug targeting or evidence that a supplement causes autoimmunity. Evidence access: Primary full text Thioredoxin is a metabolic rheostat controlling regulatory B cells. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38553615/ · DOI 10.1038/s41590-024-01798-w
    Complete structured claim and evidence

  3. CRISPR–Cas9 silencing of TXNRD1 reduced IL-10-positive B-cell frequencies after CpGC stimulation.

    TXNRD1 → Human IL-10-positive regulatory B-cell differentiation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Primary human B cells; 72-hour stimulation.
    limitations
    Supports machinery dependence, not selective drug targeting or evidence that a supplement causes autoimmunity.
    nutrient_topic
    Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Myricetin
    plain_language
    Removing one component weakens the same immune program.
    primary_references
    Thioredoxin is a metabolic rheostat controlling regulatory B cells. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38553615/ · DOI 10.1038/s41590-024-01798-w
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 300–306

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary human B cells; 72-hour stimulation. · source_derived_draft · unverified_draft

    ## myricetin-breg-silencing-txnrd1 Removing one component weakens the same immune program. CRISPR–Cas9 silencing of TXNRD1 reduced IL-10-positive B-cell frequencies after CpGC stimulation. Model: Primary human B cells; 72-hour stimulation. Limitations: Supports machinery dependence, not selective drug targeting or evidence that a supplement causes autoimmunity. Evidence access: Primary full text Thioredoxin is a metabolic rheostat controlling regulatory B cells. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38553615/ · DOI 10.1038/s41590-024-01798-w
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards