{"id":"fda0cda7-d50b-5f34-90f8-99ea26ee708f","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-breg-myricetin","predicate":"reduces","statement":"Myricetin reduced IL-10-positive B-cell frequencies and IL-10 secretion after 72-hour CpGC stimulation without reducing B-cell viability.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d7908da5-0375-5113-836b-daedd52e6a6b","mechanism_event_label":"An immune-suppressing B-cell population also depends on redox machinery.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"d7d00d06-34cf-5c76-9f8b-124726657a6a","slug":"human-il10-breg-differentiation","display_name":"Human IL-10-positive regulatory B-cell differentiation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d7908da5-0375-5113-836b-daedd52e6a6b","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-breg-myricetin-event","event_type":"observed_relationship","label":"An immune-suppressing B-cell population also depends on redox machinery.","description":"Myricetin reduced IL-10-positive B-cell frequencies and IL-10 secretion after 72-hour CpGC stimulation without reducing B-cell viability.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d7d00d06-34cf-5c76-9f8b-124726657a6a","slug":"human-il10-breg-differentiation","display_name":"Human IL-10-positive regulatory B-cell differentiation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary human B cells; methods specify 10 micromolar myricetin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Extended Data figure caption in retrieved text says 10 mM, conflicting with methods; use methods dose provisionally and retain the reporting discrepancy. D9-only results are not assigned to myricetin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An immune-suppressing B-cell population also depends on redox machinery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Thioredoxin is a metabolic rheostat controlling regulatory B cells. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38553615/ · DOI 10.1038/s41590-024-01798-w","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"63dc20bb-1075-5b53-9866-2f10cc53dd95","evidence_kind":"source_excerpt","locator":"Lines 292-298","start_line":292,"end_line":298,"excerpt":"## myricetin-breg-myricetin\nAn immune-suppressing B-cell population also depends on redox machinery.\nMyricetin reduced IL-10-positive B-cell frequencies and IL-10 secretion after 72-hour CpGC stimulation without reducing B-cell viability.\nModel: Primary human B cells; methods specify 10 micromolar myricetin.\nLimitations: Extended Data figure caption in retrieved text says 10 mM, conflicting with methods; use methods dose provisionally and retain the reporting discrepancy. D9-only results are not assigned to myricetin.\nEvidence access: Primary full text\nThioredoxin is a metabolic rheostat controlling regulatory B cells. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38553615/ · DOI 10.1038/s41590-024-01798-w","model_system":"Primary human B cells; methods specify 10 micromolar myricetin.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}