Component
Human aminopeptidase A / ENPEP
Context-specific entity; species, compartment and exposure are stated on each claim.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
CaCl2 increased aspartame hydrolysis 2.9–4.5-fold in the tested human and pig membrane preparations.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Ex vivo microvillar assays.
- limitations
- Not evidence that calcium supplements improve tolerance.
- nutrient_topic
- Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Aspartame
- plain_language
- Calcium availability affected measured enzyme activity.
- primary_references
- Metabolism of aspartame by human and pig intestinal microvillar peptidases. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8141778/ · DOI 10.1042/bj2980635
Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20) · lines 50–56
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Ex vivo microvillar assays. · source_derived_draft · unverified_draft
## aspartame-calcium-activation Calcium availability affected measured enzyme activity. CaCl2 increased aspartame hydrolysis 2.9–4.5-fold in the tested human and pig membrane preparations. Model: Ex vivo microvillar assays. Limitations: Not evidence that calcium supplements improve tolerance. Evidence access: Primary abstract Metabolism of aspartame by human and pig intestinal microvillar peptidases. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8141778/ · DOI 10.1042/bj2980635
Complete structured claim and evidence1,10-Phenanthroline or amastatin inhibited membrane aspartame metabolism by more than 78%.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Human and pig membrane inhibitor assays.
- limitations
- Inhibitor patterns support aminopeptidase A involvement, not an exclusive gene assignment.
- nutrient_topic
- Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Aspartame
- plain_language
- Metal-sensitive peptidase activity is a digestive gate.
- primary_references
- Metabolism of aspartame by human and pig intestinal microvillar peptidases. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8141778/ · DOI 10.1042/bj2980635
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20) · lines 58–64
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human and pig membrane inhibitor assays. · source_derived_draft · unverified_draft
## aspartame-metal-sensitive-hydrolysis Metal-sensitive peptidase activity is a digestive gate. 1,10-Phenanthroline or amastatin inhibited membrane aspartame metabolism by more than 78%. Model: Human and pig membrane inhibitor assays. Limitations: Inhibitor patterns support aminopeptidase A involvement, not an exclusive gene assignment. Evidence access: Primary abstract Metabolism of aspartame by human and pig intestinal microvillar peptidases. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8141778/ · DOI 10.1042/bj2980635
Complete structured claim and evidenceHuman duodenal, jejunal and ileal microvillar preparations hydrolyzed aspartame.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human membranes; parallel pig preparations.
- limitations
- Does not quantify whole-body absorption or intact circulating parent.
- nutrient_topic
- Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Aspartame
- plain_language
- Digestion is supported across sampled intestinal regions.
- primary_references
- Metabolism of aspartame by human and pig intestinal microvillar peptidases. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8141778/ · DOI 10.1042/bj2980635
Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20) · lines 42–48
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human membranes; parallel pig preparations. · source_derived_draft · unverified_draft
## aspartame-microvillar-cleavage Digestion is supported across sampled intestinal regions. Human duodenal, jejunal and ileal microvillar preparations hydrolyzed aspartame. Model: Human membranes; parallel pig preparations. Limitations: Does not quantify whole-body absorption or intact circulating parent. Evidence access: Primary abstract Metabolism of aspartame by human and pig intestinal microvillar peptidases. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8141778/ · DOI 10.1042/bj2980635
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.