Component
Controlled low-choline diet in the 2006–2007 human depletion cohort
Controlled low-choline diet in the 2006–2007 human depletion cohort. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
During deprivation, fatty liver or muscle damage developed in 77% of men, 80% of postmenopausal women and 44% of premenopausal women.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/choline-research/17490963.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824", "start_char": 0, "end_char": 1758, "text_sha256": "28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824"}
- experimental_model
- Controlled depletion/repletion with randomized folic acid supplementation
- exposure
- 550 mg choline/70 kg/day for 10 days, then less than 50 mg/70 kg/day up to 42 days; graded repletion
- limitations
- Supervised experimental depletion, not a recommended intake protocol. Liver/muscle endpoints and susceptibility differed; one cohort underlies related genetic publications.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human
- plain_language
- The response to low choline differed across people.
- primary_references
- [choline-p17490963] Sex and menopausal status influence human dietary requirements for the nutrient choline. (2007). https://pubmed.ncbi.nlm.nih.gov/17490963/ DOI: 10.1093/ajcn/85.5.1275
- tissue_or_cell_type
- 57 adults: 26 men, 16 premenopausal and 15 postmenopausal women
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 997–1008
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled depletion/repletion with randomized folic acid supplementation · source_derived_draft · unverified_draft
### choline-depletion-organs During deprivation, fatty liver or muscle damage developed in 77% of men, 80% of postmenopausal women and 44% of premenopausal women. Condition category: nutrient_deficiency nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: The response to low choline differed across people. organism: Human tissue_or_cell_type: 57 adults: 26 men, 16 premenopausal and 15 postmenopausal women experimental_model: Controlled depletion/repletion with randomized folic acid supplementation limitations: Supervised experimental depletion, not a recommended intake protocol. Liver/muscle endpoints and susceptibility differed; one cohort underlies related genetic publications. exposure: 550 mg choline/70 kg/day for 10 days, then less than 50 mg/70 kg/day up to 42 days; graded repletion evidence_span: {"source_cache": "artifacts/choline-research/17490963.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824", "start_char": 0, "end_char": 1758, "text_sha256": "28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824"} [choline-p17490963] Sex and menopausal status influence human dietary requirements for the nutrient choline. (2007). https://pubmed.ncbi.nlm.nih.gov/17490963/ DOI: 10.1093/ajcn/85.5.1275
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.