{"id":"ad18da69-4498-5ea3-86e5-934d3e6bd43f","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-depletion-organs","predicate":"can_induce","statement":"During deprivation, fatty liver or muscle damage developed in 77% of men, 80% of postmenopausal women and 44% of premenopausal women.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b3cc1140-7d0b-5e73-aa40-de85ba129d58","mechanism_event_label":"The response to low choline differed across people.","subject":{"id":"866cde7f-31a5-5bf7-b32d-cc473f49752c","slug":"human-choline-depletion-diet","display_name":"Controlled low-choline diet in the 2006–2007 human depletion cohort","entity_type_key":"chemical_species"},"object":{"id":"57aaf728-3b0f-5dda-b2e4-69ddef823b6b","slug":"human-choline-depletion-organ-dysfunction","display_name":"Fatty liver or muscle damage during controlled human choline depletion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b3cc1140-7d0b-5e73-aa40-de85ba129d58","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-depletion-organs-event","event_type":"observed_intervention","label":"The response to low choline differed across people.","description":"During deprivation, fatty liver or muscle damage developed in 77% of men, 80% of postmenopausal women and 44% of premenopausal women.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"866cde7f-31a5-5bf7-b32d-cc473f49752c","slug":"human-choline-depletion-diet","display_name":"Controlled low-choline diet in the 2006–2007 human depletion cohort","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57aaf728-3b0f-5dda-b2e4-69ddef823b6b","slug":"human-choline-depletion-organ-dysfunction","display_name":"Fatty liver or muscle damage during controlled human choline depletion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/choline-research/17490963.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824\", \"start_char\": 0, \"end_char\": 1758, \"text_sha256\": \"28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled depletion/repletion with randomized folic acid supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"550 mg choline/70 kg/day for 10 days, then less than 50 mg/70 kg/day up to 42 days; graded repletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Supervised experimental depletion, not a recommended intake protocol. 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Liver/muscle endpoints and susceptibility differed; one cohort underlies related genetic publications.\nexposure: 550 mg choline/70 kg/day for 10 days, then less than 50 mg/70 kg/day up to 42 days; graded repletion\nevidence_span: {\"source_cache\": \"artifacts/choline-research/17490963.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824\", \"start_char\": 0, \"end_char\": 1758, \"text_sha256\": \"28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824\"}\n[choline-p17490963] Sex and menopausal status influence human dietary requirements for the nutrient choline. 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